tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties

Melting point:

130-132℃

Boiling point:

454.1±45.0 °C(Predicted)

Density 

1.182

vapor pressure 

0-0Pa at 20-25℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Very Slightly)

form 

Solid

pka

7.36±0.26(Predicted)

color 

Dark Yellow

Sensitive 

Air Sensitive

InChI

InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)

InChIKey

RMULRXHUNOVPEI-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1

LogP

1.6-1.8 at 35℃ and pH7-9

Safety Information

HS Code 

2933599590

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Usage And Synthesis

Physical Form

Solid

Description

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Uses

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Preparation

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.

Hazard

Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate(571188-59-5)Related Product Information

• 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
• 1-N-BOC-4-BROMOPIPERIDINE
• Copper(II) chloride dihydrate
• Iodomethane
• sacubitril
• 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
• 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• PD 0332991 HCl
• 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester
• LEE011 (succinate)
• 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione
• 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro-
• LEE011 (hydrochloride)
• 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA
• Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-
• Palbociclib
• tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate