6-Bromobenzothiazole Chemical Properties

Melting point:

52-54℃

Boiling point:

143 °C(Press: 12 Torr)

Density 

1.748±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

0.21±0.10(Predicted)

color 

Off-white to yellow

CAS DataBase Reference

53218-26-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-37/39

RIDADR 

2811

HS Code 

29339900

6-Bromobenzothiazole Usage And Synthesis

Chemical Properties

Off-white powder

Uses

6-Bromobenzothiazole is a benzothiazole analogue. It can be used as a pharmaceutical intermediate or a raw material for the preparation of other aza-aromatic compounds.

Synthesis

The general procedure for the synthesis of 6-bromobenzothiazole from 6-aminobenzothiazole was as follows: aqueous (1.0 mL) solution of sodium nitrite (0.147 g, 2.1 mmol) was slowly added dropwise to a mixture of 6-aminobenzothiazole (0.30 g, 2.0 mmol) suspended in a 48% aqueous hydrobromic acid solution (3 mL) at 0 °C. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 30 minutes. Subsequently, the resulting solution was slowly added to a hydrochloric acid solution (concentration not specified, 5 mL) of copper (I) bromide (0.435 g, 3.0 mmol) at 0 °C. After addition, the reaction system was warmed to 60 °C and stirred for 1.5 hours. Upon completion of the reaction, the reaction mixture was cooled, alkalized with excess ammonia and extracted with ether. The organic phases were combined, washed sequentially with water and saturated saline, dried anhydrous and concentrated. Purification by Combiflash fast chromatography afforded 6-bromobenzothiazole (0.26 g). This product was subsequently converted to the target compound using a similar procedure as in Example 1 , with mass spectrometry (ESI) detection showing (M + H)+ = 413.1.

References

[1] Organic Letters, 2007, vol. 9, # 18, p. 3623 - 3625
[2] Patent: WO2004/50659, 2004, A1. Location in patent: Page 49-50
[3] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00154
[4] Patent: US2014/357651, 2014, A1. Location in patent: Paragraph 0498
[5] Patent: US9174994, 2015, B2. Location in patent: Page/Page column 126

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