5-Bromo-2-mercaptobenzothiazole Chemical Properties

Melting point:

198-200 °C(lit.)

storage temp. 

2-8°C

Appearance

Yellow to brown Solid

CAS DataBase Reference

71216-20-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

36/37/39-26-22

WGK Germany 

3

RTECS 

DL6490000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Bromo-2-mercaptobenzothiazole Usage And Synthesis

Chemical Properties

Yellow solid

Synthesis

General procedure for the synthesis of 5-bromo-2-mercaptobenzothiazole from 5-bromobenzothiazole: 5-bromobenzothiazole (214.08 mg, 1.0 mmol), 1,3-propanedithiol (325 μL, 3.0 mmol), potassium carbonate (552 mg, 4.0 mmol), and DMSO (2 mL) were added into a reaction tube equipped with a magnetic stirrer. The reaction system was displaced three times with nitrogen to remove air, followed by stirring the reaction for 12 h in an oil bath at 120 °C. Upon completion of the reaction, the reaction mixture was transferred to a dispensing funnel and washed with an appropriate amount of water. The pH of the aqueous phase was adjusted to 1-3 with dilute hydrochloric acid, followed by extraction of the organic phase with dichloromethane. The organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting crude product was purified by column chromatography to give a pink solid product (112.4 mg, 45.7% yield).

References

[1] Patent: CN108530374, 2018, A. Location in patent: Paragraph 0032; 0033

5-Bromo-2-mercaptobenzothiazole(71216-20-1)Related Product Information

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