Heterocycles Chemical Properties

Boiling point:

208.5±13.0 °C(Predicted)

Density 

1.020±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2932990090

Heterocycles Usage And Synthesis

Synthesis

GENERAL PROCEDURE: Methyl 2-(dihydro-2H-pyran-4(3H)-ylidene)acetate (7.06 mmol) was dissolved in methanol (7 mL, 1.0 M) and the solution was cooled to 0 °C. Subsequently, 10% Pd/C catalyst (2.12 mmol) was added and methanol (55 mL) was made up. Ammonium formate (35.3 mmol) was added in batches and then the reaction mixture was heated to 90 °C. After 90 minutes of reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was concentrated under vacuum to afford methyl 2-(tetrahydro-2H-pyran-4-yl)acetate, which was used in subsequent steps without further purification.

References

[1] Australian Journal of Chemistry, 2015, vol. 68, # 4, p. 660 - 679
[2] Patent: WO2004/113298, 2004, A1. Location in patent: Page 29-30
[3] Patent: WO2004/113312, 2004, A1. Location in patent: Page 23
[4] Patent: US2005/26916, 2005, A1. Location in patent: Page/Page column 73

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