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brusatol

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brusatol Basic information

Product Name:
brusatol
Synonyms:
  • 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester
  • 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
  • methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
  • Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-
  • NSC 172924
  • Yatansin
  • Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-
  • Brustaol
CAS:
14907-98-3
MF:
C26H32O11
MW:
520.53
Mol File:
14907-98-3.mol
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brusatol Chemical Properties

Boiling point:
724.3±60.0 °C(Predicted)
Density 
1.46±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka
8.81±0.70(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D +35 to +44°, c = 0.5 in acetone
LogP
0.393 (est)
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brusatol Usage And Synthesis

Uses

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Definition

ChEBI: Brusatol is a triterpenoid.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

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