brusatol
brusatol Basic information
- Product Name:
- brusatol
- Synonyms:
-
- 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester
- 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
- methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
- Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-
- NSC 172924
- Yatansin
- Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-
- Brustaol
- CAS:
- 14907-98-3
- MF:
- C26H32O11
- MW:
- 520.53
- Mol File:
- 14907-98-3.mol
brusatol Chemical Properties
- Boiling point:
- 724.3±60.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- pka
- 8.81±0.70(Predicted)
- form
- powder
- color
- white to beige
- biological source
- (Brucia javanica)
- optical activity
- [α]/D +35 to +44°, c = 0.5 in acetone
- InChIKey
- ZZZYHIMVKOHVIH-YHSWLYNENA-N
- LogP
- 0.393 (est)
brusatol Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Brucea javanica.
Uses
Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.
Definition
ChEBI: Brusatol is a triterpenoid.
Biochem/physiol Actions
Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.
in vivo
Brusatol is able to reach the tumor tissue and inhibit the Nrf2 pathway. Nude mice are injected with A549 cells to induce tumor growth, followed by a single i.p. injection of 2 mg/kg Brusatol. Nrf2 protein levels are significantly decreased at 24 h or 48 h postinjection[1].
Cisplatin (2 mg/kg) or Brusatol (2 mg/kg) alone does not inhibit tumor growth significantly, whereas in the combination group, tumor size is significantly reduced[1]. "
| Animal Model: | Athymic nude mice 4-6 wk old bearing A549 xenografts[1] |
| Dosage: | 2 mg/kg |
| Administration: | Treated i.p.; Cisplatin (2 mg/kg), Brusatol (2 mg/kg), or in combination every other day for a total of five times |
| Result: | Nrf2 protein levels were significantly decreased at 24 h or 48 h postinjection. Cisplatin or Brusatol alone did not inhibit tumor growth significantly, whereas in the combination group, tumor size was significantly reduced.?" |
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brusatol(14907-98-3)Related Product Information
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