bruceine A Chemical Properties

Boiling point:

712.6±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming

form 

Powder

pka

8.81±0.70(Predicted)

color 

White to off-white

bruceine A Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.

Uses

Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.

Definition

ChEBI: Bruceine A is a quassinoid.

Biological Activity

ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.

Physiological effects

Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.

in vitro

bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].

in vivo

oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].

target

Antifection | p65 | NF-kB | ROS

References

[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.

bruceine A(25514-31-2)Related Product Information

• YADANZIOSIDE-L
• bruceine B
• Acid Red 94
• DEHYDROBRUCEANTIN
• Bruceantin
• (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione
• bruceine E
• brusatol
• yadanziolide A
• YADANZIOLIDE-C
• (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione
• bruceine D
• Brucea javanicaseed oil
• Bruceae Fructus