CCT196969
CCT196969 Basic information
- Product Name:
- CCT196969
- Synonyms:
-
- CCT196969
- 1-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyra
- CCT196969; CCT-196969; CCT 196969
- CS-2447
- Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-
- CCT 196969,Raf,CCT196969,CCT-196969,Inhibitor,inhibit,Raf kinases
- CCT196969, 10 mM in DMSO
- CCT196969 ，S7743
- CAS:
- 1163719-56-9
- MF:
- C27H24FN7O3
- MW:
- 513.52
- Mol File:
- 1163719-56-9.mol
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CCT196969 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble
- form
- A solid
- color
- White to off-white
- InChIKey
- KYYKGSDLXXKQCR-UHFFFAOYSA-N
- SMILES
- N(C1=CC=C(OC2=C3N=CC(=O)NC3=NC=C2)C=C1F)C(NC1N(C2=CC=CC=C2)N=C(C(C)(C)C)C=1)=O
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CCT196969 Usage And Synthesis
Uses
CCT196969 is a paradox-breaking RAF inhibitor that also targets SRC and is thus effective in drug-resistant BRAF mutant melanoma.
in vivo
CCT196969 is extremely well tolerated and does not produce any significant adverse effects in vivo. It inhibits the growth of NRAS mutant DO4 tumor xenografts in nude mice. CCT196969 inhibits ERK and SRC and induce tumor regression in a PDX from the resistant tumor without causing body weight loss in the mice[1].
IC 50
BRafV600E: 0.04 μM (IC50); Braf: 0.1 μM (IC50); CRAF: 0.01 μM (IC50); LCK: 0.02 μM (IC50); SRC: 0.03 μM (IC50)
CCT196969Supplier
Nantong Innova Pharma-Tech Co., Ltd. Gold
- Tel
- 0513-80339088 13862859328
- zyz.80@163.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Shanghai YuanQi Biotechnology Co., Ltd.
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
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