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Eleutheroside E

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Eleutheroside E Basic information

Product Name:
Eleutheroside E
Synonyms:
  • Eleutheroside
  • b-D-Glucopyranoside,[(1R,3aR,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-diMethoxy-4,1-phenylene)bis-
  • [(1R,3aR,4S,6aS)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene) bis-β-D-glucopyranoside
  • ELEUTHEROSIDE E
  • (-)-SYRINGARESINOL DIGLUCOSIDE
  • (2R,3S,4R,5R,6S)-2-[4-[4-[3,5-Dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan-1-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Related CAS No: 19046-36-7 96038-87-8 66791-77-3
  • Manyprickle Acathopanax Root
CAS:
39432-56-9
MF:
C34H46O18
MW:
742.72
EINECS:
609-679-3
Product Categories:
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • Coumarins
Mol File:
39432-56-9.mol
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Eleutheroside E Chemical Properties

Melting point:
269～270℃
Boiling point:
935.7±65.0 °C(Predicted)
Density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Pyridine (Slightly, Sonicated)
form 
Solid
pka
12.45±0.70(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
FFDULTAFAQRACT-MDXYHMFDNA-N
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29389090
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Eleutheroside E Usage And Synthesis

Chemical Properties

White crystalline powder, easily soluble in water, derived from Acanthopanax senticosus.

Uses

Eleutheroside E is used in the treatment of collagen-induced arthritis. Used in the suppression of inflammatory cytokine release. Successful in the treatment of rheumatoid arthritis. Also used in the regulation of adipogenesis

Definition

ChEBI: Eleutheroside E is a lignan and a glycoside.

in vivo

Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis[1].
Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model[3].
Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice[4].

Animal Model:db/db mice[1]
Dosage:Containing 0.003% of the diet; 5 weeks
Administration:Oral
Result:Improved blood lipids, significantly reduced blood sugar and serum insulin levels, induced HOMA-IR, increased insulin sensitivity, and protected pancreatic α and β cells from diabetic damage.
Animal Model:Collageninduced arthritis (CIA) mice[3]
Dosage:15, 30, 60 mg/kg; daily; 3 weeks
Administration:Oral
Result:Reduced mean arthritis score and arthritis incidence, reduced inflammatory cell infiltration, mesenchymal formation, cartilage damage and bone erosion in CIA mice, and decreased TNF-α and IL-6.
Animal Model:Mice irradiated with 60Co-γ rays[4]
Dosage:50 mg/kg; daily; 4 weeks
Administration:Oral
Result:Improved cognitive and spatial memory impairments in irradiated mice, protected hippocampal neurons, and activated the PKA/CREB/BDNF signaling pathway.

target

NF-kB | TNF-α | IL Receptor | P450 (e.g. CYP17) | IFN-γ

Eleutheroside ESupplier

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