ELEUTHEROSIDE B1(RG) CAS#: 16845-16-2

ELEUTHEROSIDE B1(RG) Basic information

Product Name:

ELEUTHEROSIDE B1(RG)

Synonyms:

ELEUTHEROSIDE B1(RG)
2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy-
2H-1-Benzopyran-2-one, 7-(α-D-glucopyranosyloxy)-6,8-dimethoxy-
6,8-Dimethoxy-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
Eleutheroside B 1,Influenza Virus,anti-inflammatory,virus,host,Eleutheroside B1,anti-influenza,Eleutheroside B-1,Inhibitor,genes,biosynthesis,inhibit
Eleutheroside B1, 10 mM in DMSO

CAS:

16845-16-2

MF:

C17H20O10

MW:

384.34

Mol File:

16845-16-2.mol

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ELEUTHEROSIDE B1(RG) Chemical Properties

Boiling point:: 675.0±55.0 °C(Predicted)
Density: 1.524±0.06 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
pka: 12.65±0.70(Predicted)
form: Solid
color: White to off-white

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ELEUTHEROSIDE B1(RG) Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in chloroform, derived from the dried rhizome of Acanthopanax senticosus.

Uses

Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50?value of 64-125?μg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1].

Biological Activity

Eleutheroside B1, a coumarin compound, has broad-spectrum anti-human influenza virus (influenza virus) activity with IC50 values of 64-125μg/ml. It mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits mRNA expression of multiple chemokine genes and influenza virus nucleoprotein (NP) gene with low cytotoxicity. Has antiviral and anti-inflammatory activity.

in vitro

Eeutheroside B1 (100 μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells.

RT-PCR

Cell Line:	Virus-infected A549 cells
Concentration:	100 μg/ml
Incubation Time:	24 hours
Result:	The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

References

[1] Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med.?2018?Nov;42(5):2776-2792. DOI:10.3892/ijmm.2018.3863

ELEUTHEROSIDE B1(RG)Supplier

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Email: shyysw007@163.com

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Email: cwb1@biopurify.cn

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Email: tauto@tautobiotech.com

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Email: 2355253622@qq.com;

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Email: product02@bidepharm.com

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