Basic information Safety Supplier Related

ELEUTHEROSIDE B1(RG)

Basic information Safety Supplier Related

ELEUTHEROSIDE B1(RG) Basic information

Product Name:
ELEUTHEROSIDE B1(RG)
Synonyms:
  • ELEUTHEROSIDE B1(RG)
  • 2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy-
  • 2H-1-Benzopyran-2-one, 7-(α-D-glucopyranosyloxy)-6,8-dimethoxy-
  • 6,8-Dimethoxy-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
  • Eleutheroside B 1,Influenza Virus,anti-inflammatory,virus,host,Eleutheroside B1,anti-influenza,Eleutheroside B-1,Inhibitor,genes,biosynthesis,inhibit
CAS:
16845-16-2
MF:
C17H20O10
MW:
384.34
Mol File:
16845-16-2.mol
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ELEUTHEROSIDE B1(RG) Chemical Properties

Boiling point:
675.0±55.0 °C(Predicted)
Density 
1.524±0.06 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
pka
12.65±0.70(Predicted)
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ELEUTHEROSIDE B1(RG) Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in chloroform, derived from the dried rhizome of Acanthopanax senticosus.

Biological Activity

Eleutheroside B1, a coumarin compound, has broad-spectrum anti-human influenza virus (influenza virus) activity with IC50 values of 64-125μg/ml. It mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits mRNA expression of multiple chemokine genes and influenza virus nucleoprotein (NP) gene with low cytotoxicity. Has antiviral and anti-inflammatory activity.

in vitro

Eeutheroside B1 (100 μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells.

RT-PCR

Cell Line: Virus-infected A549 cells
Concentration: 100 μg/ml
Incubation Time: 24 hours
Result: The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

ELEUTHEROSIDE B1(RG)Supplier

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