ANTI-HUMAN SIRTUIN TYPE 3 (SIRT 3) Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Specific Activity

123-196RLU/min·ng

ANTI-HUMAN SIRTUIN TYPE 3 (SIRT 3) Usage And Synthesis

Uses

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biological Activity

Sirtuin 3 (Sirt3) is mainly a nuclear protein th at transfers to the mitochondria during cellular stress. In humans, Sirt3 deacetylates and activates the mitochondrial enzyme acetyl-CoA synthetase 1 (AceCS2). Sirt3 is implicated in regulating mitochondrial function and thermogenesis in brown adipocytes. Its levels have been shown to correlate with extended life span. Increased levels of Sirt3 were associated with node positive breast cancer.

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