7-Bromo-1H-indazole Chemical Properties

Melting point:

126-130 °C

Boiling point:

333.8±15.0 °C(Predicted)

Density 

1.770±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

pka

11.82±0.40(Predicted)

color 

Yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933998090

7-Bromo-1H-indazole Usage And Synthesis

Synthesis

The general procedure for the synthesis of 7-bromo-1H-indazole from 7-aminoindazole was as follows: 7-aminoindazole (3.45 g, 25.9 mmol) was dissolved in concentrated hydrobromic acid (25 mL), diluted with water (8.5 mL), and cooled to -10 °C. In another vessel, sodium nitrite (755 mg, 10.9 mmol) was dissolved in water (11.5 mL), cooled and slowly added to the above solution. Subsequently, solid sodium nitrite (1.14 g, 16.5 mmol) was added in batches. The reaction solution was stirred at -5°C for 15 minutes, and then a concentrated hydrobromic acid (11.5 mL) solution of cooled cuprous bromide (3.94 g, 27.5 mmol) was added dropwise over 15 minutes. The reaction mixture was stirred at room temperature for 2 hours and then neutralized with saturated sodium bicarbonate solution. The neutralized mixture was diluted with water (50 mL), filtered and the filter cake was washed with ethyl acetate (300 mL). The filtrate layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 7-bromo-1H-indazole (1.88 g, 37% yield).

References

[1] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 25-26
[2] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 26
[3] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 65-66

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