7-Bromo-1-tetralone Chemical Properties

Melting point:

78 °C

Boiling point:

157°C/8mmHg(lit.)

Density 

1.511±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow to Dark green

λmax

305nm(EtOH)(lit.)

InChI

InChI=1S/C10H9BrO/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6H,1-3H2

InChIKey

YGVDCGFUUUJCDF-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=CC(Br)=C2)CCC1

CAS DataBase Reference

32281-97-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39-24/25

WGK Germany 

2

HazardClass 

IRRITANT

HS Code 

29147000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 3

MSDS

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7-Bromo-1-tetralone Usage And Synthesis

Chemical Properties

White to yellow to tan powder or crystal

Uses

7-Bromo-1-tetralone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

A mixture of 4-(8-methoxynaphthalen-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline maleate (57 g, 223 mmol), potassium hydroxide (43 g, 760 mmol), and hydrazine hydrate (26 m1, 830 mmol) in diethylene glycol (2,865 ml) was stirred for 3 hr at 195 ??C. After cooling to below 40??C, the mixture was diluted with water (300 ml), poured into 3 M NaOH and washed three times with dichloromethane. Brine was added to break up the emulsion. The aqueous layer was acidified to pH 1 with 6M HCl and extracted three times with methyl tert-butyl ether. The combined organic extracts were dried with magnesium sulfate to give 4-(4-bromophenyl)butyric acid (41 g, 75%). The product of the previous step (97 g, 397 mmol) was added to polyphosphoric acid (580 g) and the resulting mixture was stirred at 90??C for 10 min. After cooling to 0??C, 6 M NaOH was added and the mixture was extracted with methyl tert-butyl ether. The organic extract was dried with magnesium sulfate to give 7-bromo-3,4-dihydronaphthalen-1-one (49 g, 55%), chromatographed (6:1 to 4:1 heptane/ethyl acetate) and recrystallized from cyclohexane to give the product 7-bromo-3,4-dihydro-2H-1-naphthalenone.

7-Bromo-1-tetralone(32281-97-3)Related Product Information

• Nabumetone
• beta-Tetralone
• 1,2,3,4-Tetrahydronaphthalene
• 4'-Bromoacetophenone
• 2-Bromoacetophenone
• 1-Bromonaphthalene
• 2-Bromonaphthalene
• Decahydronaphthalene
• 1-Tetralone
• 7-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine
• 7-(TRIFLUOROMETHYL)-1-TETRALONE
• 7-Nitro-1-tetralone
• 7-Nitro-2-tetralone
• 7-(1,1-Dimethylethyl)-3,4-dihydro-1(2H)-naphthalenone
• 7-BROMO-2-METHYL-2H-INDAZOLE
• 7-Bromo-1H-indazole
• Bromine
• 7-BROMO-4,4-DIMETHYL-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE