1-Tetralone Chemical Properties

Melting point:

2-7 °C(lit.)

Boiling point:

113-116 °C6 mm Hg(lit.)

Density 

1.099 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.568(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform, Ethyl Acetate (Slightly)

form 

Liquid

color 

brown

Water Solubility 

insoluble

BRN 

607374

InChIKey

XHLHPRDBBAGVEG-UHFFFAOYSA-N

CAS DataBase Reference

529-34-0(CAS DataBase Reference)

NIST Chemistry Reference

1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0)

EPA Substance Registry System

1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-20/22-20/21/22

Safety Statements 

23-24/25-36

WGK Germany 

3

RTECS 

QK4375000

TSCA 

Yes

HS Code 

29143900

Hazardous Substances Data

529-34-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg

MSDS

• Language:English Provider:1-Tetralone
• Language:English Provider:SigmaAldrich
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1-Tetralone Usage And Synthesis

Chemical Properties

Clear amber to brown oily liquid

Uses

1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8

Purification Methods

Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]

1-Tetralone(529-34-0)Related Product Information

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