Basic information Chemical properties Uses Production Category Toxicity grading Acute toxicity Hazardous characteristics of the explosive Flammability hazard Storage and transportation properties Extinguishing agent Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Esters >  Lactones >  Gamma-butyrolactone(GBL)

Gamma-butyrolactone(GBL)

Basic information Chemical properties Uses Production Category Toxicity grading Acute toxicity Hazardous characteristics of the explosive Flammability hazard Storage and transportation properties Extinguishing agent Safety Supplier Related

Gamma-butyrolactone(GBL) Basic information

Product Name:
Gamma-butyrolactone(GBL)
Synonyms:
  • FEMA 3291
  • GAMMA-BUTYROLACTONE
  • GAMA-BUTYROLACTONE
  • GAMMA-HYDROXYBUTYRIC ACID LACTONE
  • GBL
  • GBL-EL
  • G-BUTYROLACTONE
  • endo-cis-5-norbornene-endo-2,3-dicarboxylic anhydride
CAS:
96-48-0
MF:
C4H6O2
MW:
86.09
EINECS:
202-509-5
Product Categories:
  • organic interme-
  • Pharmaceutical Intermediates
  • -
  • Heterocycles
  • Miscellaneous Reagents
  • Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines
Mol File:
96-48-0.mol
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Gamma-butyrolactone(GBL) Chemical Properties

Melting point:
−45 °C(lit.)
Boiling point:
204-205 °C(lit.)
Density 
1.12 g/mL at 25 °C(lit.)
vapor density 
3 (vs air)
vapor pressure 
1.5 mm Hg ( 20 °C)
refractive index 
n20/D 1.436(lit.)
FEMA 
3291 | 4-HYDROXYBUTANOIC ACID LACTONE
Flash point:
209 °F
storage temp. 
2-8°C
form 
neat
explosive limit
16%
Water Solubility 
MISCIBLE
Merck 
13,1596
JECFA Number
219
BRN 
105248
Stability:
Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents.
InChIKey
YEJRWHAVMIAJKC-UHFFFAOYSA-N
CAS DataBase Reference
96-48-0(CAS DataBase Reference)
NIST Chemistry Reference
«gamma»-Butyrolactone(96-48-0)
EPA Substance Registry System
2(3H)-Furanone, dihydro-(96-48-0)
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Safety Information

Hazard Codes 
Xn,F
Risk Statements 
22-36-67-41-20/21/22-11
Safety Statements 
26-36-39-36/37-16
WGK Germany 
1
RTECS 
LU3500000
Autoignition Temperature
851 °F
TSCA 
Yes
HS Code 
29322980
Hazardous Substances Data
96-48-0(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 17.2 ml/kg (Smyth)

MSDS

  • Language:English Provider:BLO
  • Language:English Provider:SigmaAldrich
  • Language:English Provider:ACROS
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Gamma-butyrolactone(GBL) Usage And Synthesis

Chemical properties

Colorless transparent liquid It is miscible with water and the general organic and slightly soluble in aliphatic hydrocarbons.

Uses

  • It is an important organic synthesis intermediate which can be used to synthesize indole butyric acid, butyric acid, succinic acid, α-pyrrolidone, N-methylpyrrolidone, vinyl pyrrolidone, acetyl-γ-butyrolactone, cyclopropylamine, ciprofloxacin, vitamin B1, chlorophyll and so on;
  • It is a non-toxic high boiling point solvent with high solubility and safe and convenient usage and management;
  • It is used as an extractant for butadiene, aromatic, advanced grease petroleum processing;
  • It is used as an acrylonitrile fiber spinning solvent in the chemical fiber industry. 
  • It is a thinner and curing agent commonly used in wool, nylon, acrylonitrile and other fiber dyeing auxiliaries and other chemical industries.

Production

Maleic anhydride hydrogenation method is an advanced technology developed in 1970s. It can produce tetrahydrofuran and γ-butyrolactone in any proportion with a hydrogenation reaction, and the usual ratio is tetrachlorofuran: γ-butyrolactone = 3-4:1.
There are many production enterprises, but usually in small scale. The average level is 300t/a. The production capacity account for 30% of the total domestic production capacity.  2.1, 4-butanediol dehydrogenation reactor is a tube array reactor, filled with flake copper catalyst (with zinc oxide as the carrier). The reaction temperature is controlled at 230-240 ° C. The yield of the product is obtained by reduced pressure distillation of and the yield is above 77%.

Category

Flammable substance

Toxicity grading

Middle

Acute toxicity

oral-rat LD50: 1540 mg/kg; oral-mouse LD50: 1720 mg/kg

Hazardous characteristics of the explosive

Explosible when react with butanol, 2,4-dichlorophenol and sodium hydroxide

Flammability hazard

Flammable in case of heat, open flame; being able to react with oxidant; releasing toxic pungent smoke when in the process of pyrolysis.

Storage and transportation properties

Make sure ventilating, low temperature and drying in the warehouse; separate from the oxidant; prevent fires.

Extinguishing agent

Dry powder, carbon dioxide, foam

Description

Dihydro-2(3H)-furanone. An endogenous neuroregulator made from gamma-amino butyrate and the precursor of gamma hydroxybutyrate. It causes selective increase of brain dopamine by inhibiting its release from nerve terminals. The compound has sedative properties at low doses and produces surgical anesthesia at high doses. It is also used as an industrial solvent and precursor.

Chemical Properties

γ-Butyrolactone has a faint, sweet, aromatic, slightly buttery odor.

Chemical Properties

Oily, colorless, clear liquid. Faint, pleasant odor.

Chemical Properties

colourless oily liquid

Occurrence

Reported found as a constituent in coffee aroma; a volatile flavor component in roasted filberts as well. Also reported found in tomato, potato, soybeans, beans, vinegar, mushrooms, roasted chicken, beef, cider, beer, wine, scallops and clams.

Uses

r-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent, absorbent, dispersing agent, solid stain, Coagulation Reagent.

Uses

Intermediate in the synthesis of polyvinylpyrrolidone, DL-methionine, piperidine, phenylbutyric acid, thiobutyric acids. Solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene. Constituent of paint removers, textile aids, drilling oils.

Definition

ChEBI: A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.

Preparation

From acetylene and formaldehyde, also from a number of alternative sources; ethylene chlorohydrin, glutamic acid, γ-hydroxybutyric acid solutions, tetrahydrofuran, vinyl-acetic acid.

Aroma threshold values

Detection: 20 to 50 ppm

Taste threshold values

Taste characteristic at 75 ppm: milky, creamy with fruity peach-like afternotes.

General Description

Clear colorless oily liquid with a pleasant odor.

Air & Water Reactions

Hygroscopic. Soluble in water.

Reactivity Profile

gamma-Butyrolactone can react with oxidizing materials, inorganic acids and bases, alcohols and amines. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. gamma-Butyrolactone is volatile with steam. . The combination of the lactone, butanol, 2,4-dichlorophenol, and sodium hydroxide in the attempted synthesis of 2,4-dichlorophenoxybutyric acid caused a thermal runaway reaction that eventually exploded, [CISHC Chem. Safety Summ., 1977, 48, 3].

Hazard

Toxic by ingestion. Questionable carcino- gen.

Fire Hazard

gamma-Butyrolactone is combustible.

Safety Profile

Moderately toxic by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Less acutely toxic than ppropiolactone. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. Potentially explosive reaction with butanol + 2,4 dichlorophenol + sodium hydroxide. When heated to decomposition it emits acrid and irritating fumes.

Potential Exposure

Used as a chemical intermediate for making other chemicals, including pesticides, cosmetics, and pharmaceuticals; as a solvent for paint, nail polish removers, and industrial chemicals. Used in electronics, drilling and petroleum industries as a stabilizer and solvent. Used as a flavoring agent in various foods and beverages, including grains and breakfast foods, candy, and alcoholic and nonalcoholic drinks. Drug of abuse: the United States Food and Drug Administration has warned the public not to purchase or consume products, containing gamma-butyrolactone (GBL). FDA has also asked the companies that manufacture these products to voluntarily recall them. The agency has received reports of serious health problems—some that are potentially life-threatening—associated with the use of these products. Although labeled as dietary supplements and marketed under various brand names, these products are illegally marketed unapproved new drugs. False advertising claims include building muscles, improved physical performance, enhanced sex, reduced stress and induced sleep

Shipping

Listed by some sources as unregulated. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.

Purification Methods

Dry the lactone over anhydrous CaSO4, then fractionally distil it. Handle it in a fume cupboard due to its TOXICITY. [Beilstein 17 V 7.]

Incompatibilities

4-Butyrolactone is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, alcohols, amines, strong and inorganic acids, strong bases. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. It is hygroscopic and volatile with steam. Combustible; vapor may form explosive mixture with air.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.

Gamma-butyrolactone(GBL)Supplier

Hubei YuanCheng SaiChuang Technology Co., Ltd. Gold
Tel
021-68580270 18121115343
Email
foodinfo@yccreate.com
Products Intro
Product Name:gaMMa-Butyrolactone
CAS:96-48-0
Purity:99%HPLC Package:16RMB/1KG,5KG,25KG
Hefei TNJ Chemical Industry Co.,Ltd. Gold
Tel
+86 (551) 65418695 65418696
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info@tnjchem.com
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Product Name:GBL;Gamma-Butyrolactone
CAS:96-48-0
Purity:99.9%Min. Package:200kg/galvanized drum, 80 drums/20"FCL (16mt) Remarks:Manufacturer
ShanXi Tuoyuxinghua Technology Co., Ltd. Gold
Tel
0913-2123492
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3055593758@qq.com
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Product Name:gamma-Butyrolactone
CAS:96-48-0
Purity:99% Package:500g,5kg ,10kg,1T
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel
021-20337333/400-620-6333
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sale@aladdin-e.com
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Product Name:γ-Butyrolactone
CAS:96-48-0
Purity:AR, >=99% Package:250ML/69.00;
Zhejiang Realsun Chemical Industry Co., Ltd Gold
Tel
0576-88312588 0576-88312598
Email
marketing@realsunchem.com
Products Intro
Product Name:gamma-Butyrolactone
CAS:96-48-0
Purity:99.5MIN