GAMMA-CHLOROBUTYROPHENONE Chemical Properties

Melting point:

19-20 °C (lit.)

Boiling point:

130-133 °C4 mm Hg

Density 

1.137 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.544(lit.)

Flash point:

>230 °F

BRN 

878974

CAS DataBase Reference

939-52-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

23-24/25

RIDADR 

UN 2927 6.1/PG 1

WGK Germany 

3

HS Code 

2914790090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

GAMMA-CHLOROBUTYROPHENONE Usage And Synthesis

Uses

4-Chlorobutyrophenone may be used in the preparation of silyl enol ether, Z-4-chloro-1-phenyl-1-trimethylsilyloxybut-1-ene. It may be used as starting material in the preparation of 8-arylimidazopyridines.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 1455, 1957 DOI: 10.1021/ja01563a049

General Description

4-Chlorobutyrophenone is a chloro ketone. Preparation of 4-chlorobutyrophenone is reported.

Purification Methods

Fractionate the ketone several times using a short column. It recrystallises from pet ether at -20o as glistening white rosettes and is filtered at 0o, and dried in a vacuum desiccator over H2SO4. The semicarbazone has m 136-137o. [Conant et al. J Am Chem Soc 46 1882 1924, Cloke J Chem Soc 1174 1929, Hart & Curtis J Am Chem Soc 79 931 1957, Beilstein 7 IV 711.]

GAMMA-CHLOROBUTYROPHENONE(939-52-6)Related Product Information

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