Basic information Safety Supplier Related

napyradiomycin A1

Basic information Safety Supplier Related

napyradiomycin A1 Basic information

Product Name:
napyradiomycin A1
Synonyms:
  • napyradiomycin A1
  • 3,4a-Dichloro-6,8-dihydroxy-3,4,4a,10a-tetrahydro-2,2-dimethyl-10a-(3,7-dimethyl-2,6-octadienyl)-2H-naphtho[2,3-b]pyran-5,10-dione
  • Napyradiomycin A
  • WS-9558A
  • 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-, (3R,4aR,10aS)-
CAS:
103106-24-7
MF:
C25H30Cl2O5
MW:
481.413
Product Categories:
  • Antibiotic
Mol File:
103106-24-7.mol
More
Less

napyradiomycin A1 Chemical Properties

Boiling point:
642.5±55.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form 
A solid
pka
6.14±0.70(Predicted)
More
Less

Safety Information

HS Code 
29419000
Toxicity
mouse,LD50,intraperitoneal,> 250mg/kg (250mg/kg),Journal of Antibiotics. Vol. 39, Pg. 487, 1986.
More
Less

napyradiomycin A1 Usage And Synthesis

Description

Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities. It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 μg/ml). Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 μM in rat uterine homogenates). It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).

Uses

Napyradiomycin derivatives have antibacterial and tumor properties. Napyradiomycin A1 is a secondary metabolite isolated from Streptomyces. It is also an antibacterial antibiotic and an inhibitor of mitochondrial complexes I and II.

Definition

ChEBI: Napyradiomycin A1 is a member of menaquinones.

napyradiomycin A1Supplier

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com