Butyrophenone Chemical Properties

Melting point:

11-13 °C(lit.)

Boiling point:

228-230 °C(lit.)

Density 

1.021 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.520(lit.)

Flash point:

192 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

0.988

color 

Clear colorless to yellow

Odor

at 100.00 %. camphor cherry walnut hazelnut

Odor Type

camphoreous

Water Solubility 

Insoluble in water.

BRN 

508305

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

LogP

2.770

CAS DataBase Reference

495-40-9(CAS DataBase Reference)

NIST Chemistry Reference

1-Butanone, 1-phenyl-(495-40-9)

EPA Substance Registry System

1-Butanone, 1-phenyl- (495-40-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41-43

Safety Statements 

26-36/37/39-24/25-23

WGK Germany 

3

TSCA 

Yes

HS Code 

29143900

MSDS

• Language:English Provider:n-Butyrophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Butyrophenone Usage And Synthesis

Description

Butyrophenone is a chemical compound with the formula C10H12O. Butyrophenone has been used to study the relationship between the electrolyte counter-ion concentration and the critical micelle concentration for several surfactants. It has been used to generate PhCO+ ions by 70 eV electron ionization. Some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. They can interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class; Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine).

References

1. https://en.wikipedia.org/wiki/Butyrophenone
2. http://www.rightdiagnosis.com/medical/butyrophenone.htm
3. http://www.sigmaaldrich.com/catalog/product/aldrich/124338?lang=en&region=CA

Chemical Properties

colourless to yellow liquid

Uses

Butyrophenone is used as intermediates of Liquid Crystals

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

The Journal of Organic Chemistry, 61, p. 376, 1996 DOI: 10.1021/JO951500R
Tetrahedron Letters, 30, p. 6357, 1989 DOI: 10.1016/S0040-4039(01)93893-6

Biochem/physiol Actions

Butyrophenones constitutes neuroleptic drugs and interacts with the opiate receptor by inhibiting the stereospecific binding of 3H-naloxone.

Butyrophenone(495-40-9)Related Product Information

• 2-Butanone oxime
• 4-Methyl-2-pentanone
• 1-Phenyl-2-nitropropene
• 2,4-Dichlorobutyrophenone
• PHENYL VALERATE
• Cyclopropyl 4-methoxyphenyl ketone
• Benzoylferrocene
• 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one
• 2-ACETYL-1-TETRALONE
• Benzoylcyclohexane
• CYCLOPENTYL PHENYL KETONE
• LAPACHOL
• Cyclopropyl phenyl ketone
• 4-Chloro-4'-fluorobutyrophenone
• 2-Butanone
• Raspberry Ketone
• Propiophenone
• Phenylacetic acid