Basic information Description References Safety Supplier Related
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Butyrophenone

Basic information Description References Safety Supplier Related

Butyrophenone Basic information

Product Name:
Butyrophenone
Synonyms:
  • 1-PHENYL-1-BUTANONE
  • 1-Butanone,1-phenyl-
  • 1-phenyl-1-butanon
  • 1-phenyl-butan-1-one
  • 1-Phenylbutan-1-one
  • Butyrylbenzene
  • Propyl phenyl ketone
  • N-BUTANOPHENONE
CAS:
495-40-9
MF:
C10H12O
MW:
148.2
EINECS:
207-799-7
Product Categories:
  • Building Blocks
  • C10
  • Carbonyl Compounds
  • Chemical Synthesis
  • Ketones
  • Organic Building Blocks
  • Pharmaceutical Intermediates
  • Aromatic Ketones (substituted)
  • ketone
Mol File:
495-40-9.mol
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Butyrophenone Chemical Properties

Melting point:
11-13 °C(lit.)
Boiling point:
228-230 °C(lit.)
Density 
1.021 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.520(lit.)
Flash point:
192 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
Specific Gravity
0.988
color 
Clear colorless to yellow
Odor
at 100.00 %. camphor cherry walnut hazelnut
Odor Type
camphoreous
Water Solubility 
Insoluble in water.
BRN 
508305
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
LogP
2.770
CAS DataBase Reference
495-40-9(CAS DataBase Reference)
NIST Chemistry Reference
1-Butanone, 1-phenyl-(495-40-9)
EPA Substance Registry System
1-Butanone, 1-phenyl- (495-40-9)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
41-43
Safety Statements 
26-36/37/39-24/25-23
WGK Germany 
3
TSCA 
Yes
HS Code 
29143900

MSDS

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Butyrophenone Usage And Synthesis

Description

Butyrophenone is a chemical compound with the formula C10H12O. Butyrophenone has been used to study the relationship between the electrolyte counter-ion concentration and the critical micelle concentration for several surfactants. It has been used to generate PhCO+ ions by 70 eV electron ionization. Some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. They can interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class; Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine).

References

1. https://en.wikipedia.org/wiki/Butyrophenone
2. http://www.rightdiagnosis.com/medical/butyrophenone.htm
3. http://www.sigmaaldrich.com/catalog/product/aldrich/124338?lang=en&region=CA

Chemical Properties

colourless to yellow liquid

Uses

Butyrophenone is used as intermediates of Liquid Crystals

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

The Journal of Organic Chemistry, 61, p. 376, 1996 DOI: 10.1021/JO951500R
Tetrahedron Letters, 30, p. 6357, 1989 DOI: 10.1016/S0040-4039(01)93893-6

Biochem/physiol Actions

Butyrophenones constitutes neuroleptic drugs and interacts with the opiate receptor by inhibiting the stereospecific binding of 3H-naloxone.

Butyrophenone Preparation Products And Raw materials

Preparation Products

Raw materials

ButyrophenoneSupplier

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