Butyryl chloride Chemical Properties

Melting point:

−89 °C(lit.)

Boiling point:

102 °C(lit.)

Density 

1.026 g/mL at 25 °C(lit.)

vapor density 

3.7 (vs air)

vapor pressure 

39 hPa (20 °C)

refractive index 

n20/D 1.412(lit.)

RTECS 

EM0595000

Flash point:

71 °F

storage temp. 

Store below +30°C.

solubility 

Miscible with ether.

form 

Liquid

color 

Clear slightly yellow

Odor

pungent odor

explosive limit

2.5-7.3%(V)

Water Solubility 

decomposes

FreezingPoint 

-89℃

Sensitive 

Moisture Sensitive

Merck 

14,1598

BRN 

605395

InChIKey

DVECBJCOGJRVPX-UHFFFAOYSA-N

LogP

0.51 at 25℃

CAS DataBase Reference

141-75-3(CAS DataBase Reference)

NIST Chemistry Reference

Butanoyl chloride(141-75-3)

EPA Substance Registry System

Butanoyl chloride (141-75-3)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

16-23-26-36-45

RIDADR 

UN 2353 3/PG 2

WGK Germany 

1

F 

13

Autoignition Temperature

280 °C

TSCA 

Yes

HS Code 

2915 90 70

HazardClass 

3

PackingGroup 

II

Hazardous Substances Data

141-75-3(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Butyryl chloride Usage And Synthesis

Chemical Properties

Butyryl chloride is a colorless to light yellow liquid with a strong pungent odor. It undergoes vigorous hydrolysis with water; decomposes in water; soluble in almost aprotic organic solvents. It is used as an intermediate for organic synthesis for the preparation of pharmaceuticals, agrochemicals, dyes, cellulose esters, and peroxide compounds.

Uses

Butyryl chloride is used as an intermediate for the synthesis of active pharmaceutical ingredients benzoyl peroxide, t-butyl perbenzoate, and benzophenone. It is also used as an acylation reagent. Further, it is used in the preparation of peroxides such as benzoyl peroxide, benzophenone and t-butyl perbenzoate. In addition to this, it is involved in the preparation of chromones and antiproliferative agents.
Butyryl chloride has been used to esterify wood meal dissolved in the ionic liquid, 1-butyl-3-methylimidazolium chloride.

General Description

A clear colorless liquid with a sharp odor. Slightly denser than water. Flash point near 20°F. Severely irritates skin, eyes, and mucous membranes. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Fumes in air. Decomposes exothermically in water to give corrosive hydrochloric acid.

Reactivity Profile

Butyryl chloride slowly dissolves in water with decomposition and formation of a weakly acidic solution. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Extremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Inhalation may cause death as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Fire Hazard

Special Hazards of Combustion Products: Emits toxic fumes of chlorine gas

Flammability and Explosibility

Flammable

Purification Methods

Check IR to see if there is a significant peak at 3000-3500 cm-1 (br) for OH. If OH is present then reflux with less than one mole equivalent of SOCl2 for 1hour and distil directly. The fraction boiling between 85-100o is then refractionated at atmospheric pressure. Keep all apparatus free from moisture and store the product in sealed glass ampoules under N2. LACHRYMATORY; handle in a good fume hood. [Hefferich & Schaeffer Org Synth Coll Vol I 147 1941, Beilstein 2 IV 803.]

Butyryl chloride(141-75-3)Related Product Information

• Propionyl chloride
• 2,2-Dimethylbutyryl chloride
• Calcium chloride
• Sodium chloride
• Valeryl chloride
• Tosyl chloride
• Pivaloyl chloride
• Ammonium chloride
• Potassium chloride
• Polyvinyl chloride
• Sulfuryl chloride
• Choline chloride
• Oxalyl chloride
• Thionyl chloride
• Benzoyl chloride
• Polychloroprene
• Acryloyl chloride
• Chloroacetyl chloride