(R)-Glycidyl butyrate Chemical Properties

alpha 

-30 º (c=neat)

Boiling point:

197 °C(lit.)

Density 

1.032 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.428(lit.)

Flash point:

185 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform, Ethyl Acetate

form 

Liquid

color 

Clear colorless to slightly yellow

Specific Gravity

1.018

optical activity

[α]25/D 31°, neat

Water Solubility 

insoluble

BRN 

5246881

InChIKey

YLNSNVGRSIOCEU-ZCFIWIBFSA-N

CAS DataBase Reference

60456-26-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-42/43

Safety Statements 

23-36/37-45-36/37/39-26

RIDADR 

2810

WGK Germany 

3

F 

10-21

HazardClass 

6.1

PackingGroup 

III

HS Code 

29156000

MSDS

• Language:English Provider:(R)-Glycidyl butyrate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(R)-Glycidyl butyrate Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(2R)-2-Oxiranylmethyl Ester Butanoic Acid is a reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.

Uses

(R)-Glycidyl butyrate is a reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraul ic fluids; epoxy resin diluent.

Synthesis

(S)-3-Chloro-1,2-propanediol 1-(n-butyrate) (50.0 g, 0.277 mol, optical purity 99% ee) was used as a raw material and dissolved in 1,2-dichloroethane (200 ml). Potassium tert-butoxide (32.6 g, 0.291 mol) was added to the solution under cooling conditions in an ice bath. The reaction mixture was stirred for 1 hour. After completion of the reaction, the mixture was transferred to a partition funnel and washed twice with water (200 ml). The organic layer was concentrated under reduced pressure to give (R)-glycidyl butyrate (28.7 g, 72.0% yield). The optical purity of the target product was 99% ee as determined by HPLC.

References

[1] Letters in Organic Chemistry, 2011, vol. 8, # 4, p. 242 - 243
[2] Tetrahedron Letters, 2006, vol. 47, # 20, p. 3453 - 3457
[3] Patent: US2004/24254, 2004, A1. Location in patent: Page 6

(R)-Glycidyl butyrate(60456-26-0)Related Product Information

• Glycerol
• GLYCERYL MONOSTEARATE
• Allyl glycidyl ether
• Butyric Acid
• Monostearin
• Glycidyl acrylate
• Sucrose acetate isobutyrate
• Sodium Butyrate
• Dimethyl 2,2'-azobis(2-methylpropionate)
• Glycidol
• Triacetin
• (S)-GLYCIDYL BUTYRATE,(S)-(-)-GLYCIDYL BUTYRATE,(S)-(+)-GLYCIDYL BUTYRATE,(S)-(+)-GLYCIDYL BUTYRATE , EE 98%,(S)-(+)-Glycidyl butyrate, 98%, ee 98%
• Titanium tetraisopropanolate
• Titanium ethoxide
• Torezolid
• bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate
• Tedizolid Impurity 36
• Tedizolid Impurity 39