4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Chemical Properties

Melting point:

300 °C

Boiling point:

491.8±25.0 °C(Predicted)

Density 

1.259±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO, Methanol

pka

3.19±0.30(Predicted)

form 

Powder

color 

Pale Yellow to Tan

InChIKey

XWAJTVCEILFDGU-UHFFFAOYSA-N

CAS DataBase Reference

152628-03-0(CAS DataBase Reference)

Safety Information

HS Code 

29332900

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Usage And Synthesis

Chemical Properties

Light Yellow to Tan Powder

Uses

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid is a useful synthetic intermediate,a useful compound in organic synthesis.

Synthesis

Example 4: Methyl 3-methyl-4-butyrylamino-5-nitrobenzoate (II) (10 g, 0.036 mol) was suspended in 60 ml of water and heated to 70-80 °C. A suspension of sodium dithionite (21.75 g, 0.124 mol) in 60 ml of water was added slowly and heated to 90-100 °C. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 10-11 and the temperature was maintained with continued stirring until TLC detection showed complete disappearance of methyl 3-methyl-4-butyrylamino-5-nitrobenzoate. Subsequently, the pH of the reaction mixture was adjusted to 6-6.5. The resulting solid was filtered and dried at 45-50 °C to afford 2-n-propyl-4-methyl-6-carboxybenzimidazole (7.5 g, yield: 96.4%).

References

[1] Patent: WO2012/28925, 2012, A2. Location in patent: Page/Page column 18
[2] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 6, p. 1107 - 1112
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[4] Patent: WO2012/28925, 2012, A2
[5] Organic Process Research and Development, 2007, vol. 11, # 1, p. 81 - 85

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid(152628-03-0)Related Product Information

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