4-CHLOROBUTYRIC ACID Chemical Properties

Melting point:

12-16 °C(lit.)

Boiling point:

196 °C22 mm Hg(lit.)

Density 

1.24 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.451(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Ether

form 

clear liquid

pka

4.52(at RT℃)

color 

Colorless to Almost colorless

BRN 

1700264

InChIKey

IPLKGJHGWCVSOG-UHFFFAOYSA-N

CAS DataBase Reference

627-00-9(CAS DataBase Reference)

EPA Substance Registry System

4-Chlorobutyric acid (627-00-9)

Safety Information

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

MSDS

• Language:English Provider:SigmaAldrich

4-CHLOROBUTYRIC ACID Usage And Synthesis

Chemical Properties

Dark brown liquid

Uses

4-Chlorobutanoic Acid is an impurity of Levetiracetam(L331500) which is (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of Piracetam (P500800). Used as an anticonvulsant. Neuroprotective & Neuroresearch Product.

Synthesis Reference(s)

Journal of the American Chemical Society, 92, p. 5274, 1970 DOI: 10.1021/ja00720a076
The Journal of Organic Chemistry, 21, p. 883, 1956 DOI: 10.1021/jo01114a016

4-CHLOROBUTYRIC ACID(627-00-9)Related Product Information

• γ-Chlorobutyric acid ethyl ester,gamma-Chlorobutyric acid ethyl ester,4-CHLOROBUTYRIC ACID ETHYL ESTER
• 2-Chloropropionic acid
• (S)-(-)-2-Chloropropionic acid
• (2S)-2-(2-Oxopyrrolidin-1-yl)butanoic acid
• L(+)-2-Aminobutyric acid
• Gamma Butyrolactone
• (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97%
• H-ABU-OME HCL
• LevetiracetaM IMpurity B
• (S)-N-(1-aMino-1-oxobutan-2-yl)-4-chlorobutanaMide
• 2-aminobutanenitrile
• alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid
• 1,3-dihydroxypropan-2-yl 4-hydroxybenzoate
• (S)-2-Aminobutyramide hydrochloride
• 2,3-dihydroxypropyl 4-hydroxybenzoate
• SODIUM 4-HYDROXYBUTYRATE
• 2-Hydroxypyridine
• (R)-2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRAMIDE