Methyl 2-methoxy-5-sulfamoylbenzoate Chemical Properties

Melting point:

175-177 °C (lit.)

Boiling point:

439.8±55.0 °C(Predicted)

Density 

1.360±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.94±0.60(Predicted)

color 

White to Off-White

LogP

0.36

CAS DataBase Reference

33045-52-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2922500090

MSDS

• Language:English Provider:SigmaAldrich

Methyl 2-methoxy-5-sulfamoylbenzoate Usage And Synthesis

Uses

Methyl 2-methoxy-5-sulfamoylbenzoate is a reactant used in the preparation of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypog lycemic agents.

Preparation

Methyl 2-methoxy-5-aminosulfonyl benzoate is an important intermediate for the synthesis of sulpiride, which is the main drug for treatment of psychiatric disorders such as schizophrenia and depression. The synthetic route of methyl 2-methoxy-5-aminosulfonyl benzoate is composed mainly of etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification, which prepared successfully with the help of salicylic acid and methyl salicylate as precursor. The raw materials of the synthetic route are salicylic acid and methyl salicylate, which was synthesized by etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification.

synthetic procedure of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate

General Description

Methyl 2-methoxy-5-sulfamoylbenzoate is also referred to as 2-methoxy-5-sulfamoyl methyl benzoate or methyl 5-(aminosulphonyl)-2-methoxybenzoate.

Methyl 2-methoxy-5-sulfamoylbenzoate(33045-52-2)Related Product Information

• (Trifluoromethoxy)benzene
• o-Anisidine
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• Bensulfuron methyl
• Anisole
• Guaiacol
• Thiophanate-methyl
• Methylparaben
• o-Anisaldehyde
• 4-Methoxybenzoic acid
• Kresoxim-methyl
• Methyl methoxyacetate
• Methyl benzoate
• Methyl acrylate
• Methyl acetate
• Methyl
• Methyl bromide
• Ethyl 2-methoxy-5-sulfamoylbenzoate