Methylprednisolone hemisuccinate Chemical Properties

Melting point:

>230°C (dec.)

Boiling point:

689.6±55.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.

pka

4.29±0.17(Predicted)

color 

White to Off-White

LogP

2.69

CAS DataBase Reference

2921-57-5(CAS DataBase Reference)

Safety Information

HS Code 

2937290000

Methylprednisolone hemisuccinate Usage And Synthesis

Description

Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others.

Synthesis

Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%.

Chemical Properties

White or almost white, hygroscopic powder.

Uses

6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.

Uses

Glucocorticoid.

Definition

ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Methylprednisolone hemisuccinate(2921-57-5)Related Product Information

• Prednisolone
• Methylprednisolone
• D-α-Tocopherol succinate
• 6alpha-Methylprednisolone sodium succinate
• Methylprednisolone acetate
• Prednisolone-21-acetate
• Meprednisone
• Prednisone
• Methylprednisolone aceponate
• BECLOMETHASONE
• Hydrogen
• METHYLPREDNISOLONE HEMISUCCINATE USP(CRM STANDARD)
• Methylprednisolone hemisuccinate