LY 345899)
LY 345899) Basic information
- Product Name:
- LY 345899)
- Synonyms:
-
- LY 345899)
- LY-345899 (LY345899
- L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid
- inhibit,LY345899,LY-345899,Inhibitor,LY 345899,Methylenetetrahydrofolate Dehydrogenase (MTHFD)
- (2S)-2-[(4-{3-amino-1,9-dioxo-1H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl}phenyl)formamido]pentanedioic acid
- CAS:
- 10538-99-5
- MF:
- C20H21N7O7
- MW:
- 471.42
- Mol File:
- 10538-99-5.mol
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LY 345899) Chemical Properties
- Density
- 1.82±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);265.16(Max Conc. mM)
- form
- A solid
- pka
- 3.46±0.10(Predicted)
- color
- Light yellow to yellow
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LY 345899) Usage And Synthesis
Biological Activity
LY 345899, a folate analog, is also a methylenetetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively, and Ki value for MTHFD1 of 18 nM.
in vitro
LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
in vivo
LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo .