LY 345899)
LY 345899) Basic information
- Product Name:
- LY 345899)
- Synonyms:
-
- LY 345899)
- LY-345899 (LY345899
- L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid
- inhibit,LY345899,LY-345899,Inhibitor,LY 345899,Methylenetetrahydrofolate Dehydrogenase (MTHFD)
- (2S)-2-[(4-{3-amino-1,9-dioxo-1H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl}phenyl)formamido]pentanedioic acid
- LY 345899, 10 mM in DMSO
- CAS:
- 10538-99-5
- MF:
- C20H21N7O7
- MW:
- 471.42
- Mol File:
- 10538-99-5.mol
LY 345899) Chemical Properties
- Density
- 1.82±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);265.16(Max Conc. mM)
- form
- A solid
- pka
- 3.46±0.10(Predicted)
- color
- Light yellow to yellow
LY 345899) Usage And Synthesis
Uses
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1[1][2][3].
Biological Activity
LY 345899, a folate analog, is also a methylenetetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively, and Ki value for MTHFD1 of 18 nM.
in vitro
LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
in vivo
LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo .
| SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model | |
| 5-10 mg/kg | |
| Administration: | Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks |
| Result : | Displayed lower cell proliferation indices and higher cell apoptosis. Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice. |