LY 334370 HYDROCHLORIDE Chemical Properties

Boiling point:

479.1±45.0 °C(Predicted)

Density 

1.267±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

H2O: ≥5mg/mL (warmed)

form 

powder

pka

13.98±0.43(Predicted)

color 

white to tan

Safety Information

WGK Germany 

3

LY 334370 HYDROCHLORIDE Usage And Synthesis

Uses

LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.

Biological Activity

Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.

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