DEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties

Melting point:

171-174 °C

Flash point:

9℃

storage temp. 

-20°C

solubility 

DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

DEOXYCHOLIC-2,2,4,4-D4 ACID Usage And Synthesis

Description

Deoxycholic acid-d₄ (DCA-d₄) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.

Uses

Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.

Definition

ChEBI: Deoxycholic acid-2,2,4,4-d4 is a deuterated compound and a deoxycholic acid.

DEOXYCHOLIC-2,2,4,4-D4 ACID(112076-61-6)Related Product Information

• GLYCODEOXYCHOLIC ACID
• Deoxycholic acid
• Sodium deoxycholate
• DEOXYCHOLIC-2,2,4,4-D4 ACID
• OCTADECANOIC-12-D1 ACID
• CHOLIC-2,2,4,4-D4 ACID
• HEXADECANOIC-12-D1 ACID
• TETRADECANOIC-12-D1 ACID
• HEXADECANOIC-13,13-D2 ACID
• LITHOCHOLIC-2,2,4,4-D4 ACID