(D-ALA2)-LEUCINE ENKEPHALIN-ARG
(D-ALA2)-LEUCINE ENKEPHALIN-ARG Basic information
- Product Name:
- (D-ALA2)-LEUCINE ENKEPHALIN-ARG
- Synonyms:
-
- (D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH trifluoroacetate salt
- L-Tyr-D-Ala-Gly-L-Phe-L-Leu-L-Arg-OH
- Tyr-D-Ala-Gly-Phe-Leu-Arg-OH
- 1-6-beta-Neoendorphin (human), 2-D-alanine-
- 2-D-Alanine-1-6-beta-neoendorphin (human)
- Brn 4287455
- L-Arginine, N(sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-
- N(Sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginine
- CAS:
- 81733-79-1
- MF:
- C35H51N9O8
- MW:
- 725.83
- Mol File:
- 81733-79-1.mol
(D-ALA2)-LEUCINE ENKEPHALIN-ARG Chemical Properties
- Density
- 1.36±0.1 g/cm3(Predicted)
- pka
- 3.34±0.10(Predicted)
- form
- Solid
- color
- White to off-white
(D-ALA2)-LEUCINE ENKEPHALIN-ARG Usage And Synthesis
Uses
Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].
in vivo
Dalargin (25, 50 μg/kg; i.p.) shows nephroprotective effects on gentamicin-induced kidney injury in rats[2].
| Animal Model: | 290-350 g, White male rats[2] |
| Dosage: | 25, 50 μg/kg |
| Administration: | I.p. (3 h before each gentamicin injection) |
| Result: | Mitigated gentamicin-induced acutekidney injury, attenuated ROS generation and oxidative stress, alleviated histopathological changes in a renal tissue. |
IC 50
δ Opioid Receptor/DOR
References
[1] Titov MI, et al. Dalargin--a peptidny? preparat s tsitoprotektivnym de?stviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):72-6. PMID:2998416
[2] Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220(3):303-8. DOI:10.1016/j.toxlet.2013.04.023
[3] Polonski? VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo de?stviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'no? modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103(4):433-4. PMID:3032303
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