(D-Ala2)-Leu-Enkephalin Chemical Properties

Melting point:

160-163.5 °C

Boiling point:

991.9±65.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

DMF (Slightly), DMSO (Slightly)

pka

3.40±0.10(Predicted)

form 

Solid

color 

White to Off-White

Sequence

Tyr-{d-Ala}-Gly-Phe-Leu

InChI

InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24+/m1/s1

InChIKey

ZHUJMSMQIPIPTF-JMBSJVKXSA-N

SMILES

C(O)(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

(D-Ala2)-Leu-Enkephalin Usage And Synthesis

Uses

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

Definition

The leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu, Leu-enk) is a natural endogenous ligand for opiate receptors. Leu-enk is rapidly metabolized in vivo and in vitro[1]. (D-Ala2)-Leu-Enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

benefits

(D-Ala2)-Leu-Enkephalin is widely distributed in the human body and has essential physiological functions. It has a unique effect on brain cells and can activate sleeping brain cells and have a good recovery effect on the sequelae caused by brain damage. It plays an important role in immune function, including increasing the activity of the immune system, T lymphocytes, NK cells, macrophages, antiviral, and the release of gamma interferon. It can participate in immune regulation by promoting the secretion of endocrine cells by activated immune cells, thereby affecting DNA's gene regulation and expression functions.

IC 50

δ Opioid Receptor/DOR

References

[1] H. Hasegawa, S. Baba, Y. Shinohara. “Synthesis of [D-Ala2]Leu-enkephalin and [D-Ala2, D-Leu5]Leu-enkephalin with high specific tritiated activity in the leucine residue.” Journal of The Chemical Society-perkin Transactions 1 12 1 (1990): 2641–2644.

(D-Ala2)-Leu-Enkephalin(64963-01-5)Related Product Information

• PALMITOYL TETRAPEPTIDE-3
• Palmitoyl Pentapeptide
• Palmitoyl Tripeptide-5
• Acetyl Tetrapeptide-5
• NONAPEPTIDE-1
• Acetyl Octapeptide-3
• PALMITOYL TRIPEPTIDE-1
• Lipopeptide Acetate
• Palmitoyl Pentapeptide-3
• Matrixyl，PALMITOYL PENTAPEPTIDE-3
• TYR-D-ALA-GLY-PHE-MET ACOH H2O
• Hexapeptide 9
• HEXAPEPTIDE-3
• Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide
• Pentapeptide-25
• Aprotinin
• TYR-D-ALA-GLY-PHE-LEU
• H-TYR-D-ALA-GLY-PHE-LEU-ARG-ARG-ILE-ARG-OH