Basic information Safety Supplier Related

Isoflupredone Acetate

Basic information Safety Supplier Related

Isoflupredone Acetate Basic information

Product Name:
Isoflupredone Acetate
Synonyms:
  • 4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-pregna-(11-be
  • 4-diene-3,20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregna-21-acetate
  • 9-alpha-fluoroprednisoloneacetate
  • 9-fluoroprednisoloneacetate
  • 9-fluorprednisoloneacetate
  • biorinil
  • predef
  • ISOFLUPREDONE ACETATE (200 MG)
CAS:
338-98-7
MF:
C23H29FO6
MW:
420.47
EINECS:
206-423-9
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
Mol File:
338-98-7.mol
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Isoflupredone Acetate Chemical Properties

Melting point:
244-246° (dec)
alpha 
D23 +108° (c = 0.735 in dioxane)
Boiling point:
576.5±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly)
pka
12.05±0.70(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
ZOCUOMKMBMEYQV-BZIJPSHGNA-N
SMILES
[C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C |&1:0,10,12,14,17,19,22,r|
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Safety Information

HS Code 
2937220000
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Isoflupredone Acetate Usage And Synthesis

Uses

Isoflupredone Acetate is an anti-inflammatory drug used in veterinary medicine. It is a corticosteroid with both glucocorticoid and mineralocorticoid activity and has been shown to increase the frequency of severe hypokalemia in healthy cows.

Definition

ChEBI: 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate is a corticosteroid hormone.

Veterinary Drugs and Treatments

Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids can be used for its antiinflammatory or immunosuppressive effects. Labeled indications for isoflupredone include: adjunctive treatment of bovine ketosis, alleviating pain and lameness associated with musculoskeletal conditions, acute hypersensitivity reactions, adjunctive treatment of overwhelming infections with severe toxicity, shock, supportive therapy in the treatment of stress conditions (e.g., surgery), dystocia, retained placenta, inflammatory ocular conditions, snakebite and parturient paresis.
In horses, isoflupredone has been used parenterally to reduce inflammation associated with recurrent airway obstruction (RAO, “heaves”, COPD).
While the drug could be used in small animals, it is recommended to use other glucocorticoid agents instead, where there has been more experience and other approved products for dogs and cats are available.

in vivo

Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline.html" class="link-product" target="_blank">Oxytetracycline (HY-B0275)[2].

Animal Model:96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2]
Dosage:0.05 mg/kg
Administration:i.m.; on days 2 and 4 after the challenge
Result:Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers. Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

Toxics Screening Level

The ITSL for Isoflupredone Acetate is 0.01 μg/m3 based on annual averaging.

Isoflupredone AcetateSupplier

GUANGZHOU TOPWORK CHEMISTRY CO.,LTD. Gold
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J & K SCIENTIFIC LTD.
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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Syntechem Co.,Ltd
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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sj_scrc@sinopharm.com
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Isoflupredone Acetate(338-98-7)Related Product Information