METHYL 1-HYDROXY-1-CYCLOPROPANE CARBOXYLATE, 90 Chemical Properties

Boiling point:

70°C/13mmHg

Density 

1.346±0.06 g/cm3(Predicted)

Flash point:

17℃

storage temp. 

Sealed in dry,2-8°C

solubility 

Dichloromethane, Methanol

form 

Liquid

pka

13.14±0.20(Predicted)

color 

Clear yellow

Safety Information

Risk Statements 

11

Safety Statements 

16

RIDADR 

3277

HS Code 

29162090

METHYL 1-HYDROXY-1-CYCLOPROPANE CARBOXYLATE, 90 Usage And Synthesis

Uses

1-Hydroxycyclopropanecarboxylic Acid Methyl Ester is a compound useful in organic synthesis.

Synthesis

Methyl 1-aminocyclopropylcarboxylate (3.41g, 29.6mmol, 1.0eq) was dissolved in 40ml of sulfuric acid aqueous solution A (prepared by adding 1.62mL of 98% concentrated sulfuric acid to water, the molar equivalent of sulfuric acid was 1.0eq), ice The bath was cooled to 0-5° C., 10 ml of sodium nitrite (2.25 g, 32.6 mmol, 1.1 eq) aqueous solution was added to the reaction solution, and the mixture was stirred at room temperature for 1 hour. Then, the above reaction was added dropwise to 100 ml of refluxing sulfuric acid aqueous solution B (prepared by adding 1.62 mL of 98% concentrated sulfuric acid to water, and the molar equivalent of sulfuric acid was 1.0 eq). After the dropwise addition was completed, the heating was stopped, cooled to room temperature, and the reaction was detected by TLC, extracted three times with ethyl acetate (3*100 mL), the organic phases were combined, dried with anhydrous magnesium sulfate, filtered, and the organic phase was concentrated to obtain 1-hydroxyl -Methyl 1-cyclopropanecarboxylate (2.57 g, 22.1 mmol), colorless oily liquid, yield 74.8%.

Chemical Properties

Clear yellow liquid

Uses

1-Hydroxycyclopropanecarboxylic Acid Methyl Ester (cas# 33689-29-1) is a compound useful in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 1269, 1984 DOI: 10.1016/S0040-4039(01)80131-3

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