1-(2-Methoxyphenyl)piperazine Chemical Properties

Melting point:

35-40 °C (lit.)

Boiling point:

130-133 °C/0.1 mmHg (lit.)

Density 

1.095 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.575(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Liquid After Melting

pka

8.98±0.10(Predicted)

color 

Clear colorless to yellow

Water Solubility 

Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water

Sensitive 

Air Sensitive

BRN 

167888

InChI

InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3

InChIKey

VNZLQLYBRIOLFZ-UHFFFAOYSA-N

SMILES

N1(C2=CC=CC=C2OC)CCNCC1

LogP

1.67

CAS DataBase Reference

35386-24-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-28A-36

RIDADR 

UN 3263 8/PG 3

WGK Germany 

3

F 

3-10

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29349990

MSDS

• Language:English Provider:1-(2-Methoxyphenyl)piperazine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-(2-Methoxyphenyl)piperazine Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid after melting

Uses

A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).

Uses

It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.

Uses

1-(2-Methoxyphenyl)piperazine can be used:

• To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
• To prepare cyclic amine substituted Tr?ger′s base derivatives.
• To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

Definition

ChEBI: 1-(2-methoxyphenyl)piperazine is a member of piperazines.

1-(2-Methoxyphenyl)piperazine(35386-24-4)Related Product Information

• 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
• 2-Methylpiperazine
• Piperazine
• N-Aminoethylpiperazine
• Piperacillin
• 2-Ethylhexyl ferulate
• 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%
• 4-(3-Hydroxypropylamino)-1,3-dimethyluracil
• O-DesMethyl Urapidil
• 6-[(3-chloropropyl)amino]-1,3-dimethyluracil
• 2-Demethoxy-2-chloro urapidil
• Urapidil impurity 7
• 1,3-Dimethylbarbituric acid
• 2-Demethoxy-4-methoxy urapidil
• 3-[4-(2-methoxyphenyl)-1-piperazinyl]propanenitrile
• 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
• 1-(4-Methoxyphenyl)piperazine
• Propiophenone