NICOTINIC ACID MONONUCLEOTIDE Chemical Properties

Melting point:

>115°C (dec.)

storage temp. 

−20°C

solubility 

Methanol (Slightly, Heated), Water(Slightly)

form 

Solid

color 

White to Off-White

biological source

animal

Stability:

Hygroscopic

InChI

InChI=1/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/t7-,8-,9-,10-/s3

InChIKey

JOUIQRNQJGXQDC-NLNRFTKUNA-N

SMILES

[C@@H]1([C@H](O)[C@H](O)[C@@H](COP([O-])(=O)O)O1)[N+]1C=CC=C(C(=O)O)C=1 |&1:0,1,3,5,r|

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

NICOTINIC ACID MONONUCLEOTIDE Usage And Synthesis

Uses

A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.

Biological Activity

Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast. Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT) and nicotinate mononucleotide adenylyltransferase. NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor.

Synthesis

Nicotinic acid mononucleotide is prepared by the reaction of 2,3-dicarboxypyridine and 5-phosphoribosyl-1-pyrophosphate. The steps are as follows:
With phosphoribosyl pyrophosphate-quinolinate phosphoribosyltransferase; magnesium chloride In aq. phosphate buffer at 37℃; for 6h; pH=7.0; Enzymatic reaction.

NICOTINIC ACID MONONUCLEOTIDE(321-02-8)Related Product Information

• β-Nicotinamide Adenine Dinucleotide Sodium Salt Hydrate
• β-Nicotinamide Mononucleotide
• Nicotinic Acid Riboside
• SODIUM NICOTINATE
• NICOTINIC ACID HYDRAZIDE
• NICOTINIC-D4 ACID
• Ethyl nicotinate
• Nicotinic acid
• METHYLENEDIPHOSPHONIC ACID
• Methyl nicotinate
• DIAMOND
• Cyanuric acid
• nicotinic acid mononucleotide adenylyltransferase
• DEAMIDO NAD SODIUM SALT
• NICOTINIC ACID MONONUCLEOTIDE