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METHYLENEDIPHOSPHONIC ACID

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METHYLENEDIPHOSPHONIC ACID Basic information

Product Name:
METHYLENEDIPHOSPHONIC ACID
Synonyms:
  • [α,β-Methylene]diphosphoric acid
  • Methylenediphosphonic acid, Medronic acid
  • Medronic acid, Methanediylbis(phosphonic acid)
  • Methylenediphosphonic acid, methylene diphosphoric acid, Methylenediphosphonic Acid
  • Phosphonic acid, P , P '-methylenebis-
  • Methylene diphosphophonic acid
  • Methylenediphosphonic acid 99%
  • methylenediphosphonate
CAS:
1984-15-2
MF:
CH6O6P2
MW:
176
EINECS:
217-851-0
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Analytical Chemistry
  • Organic Building Blocks
  • Phosphonic/Phosphinic Acids
  • Phosphorus Compounds
  • Ligands for Pharmaceutical Research
  • Radiopharmaceutical Chemistry (Chelating Reagents)
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
1984-15-2.mol
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METHYLENEDIPHOSPHONIC ACID Chemical Properties

Melting point:
197-199 °C(lit.)
Boiling point:
583.2±60.0 °C(Predicted)
Density 
2.111±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO : 250 mg/mL (1420.45 mM; Need ultrasonic)
pka
1.43±0.10(Predicted)
form 
Moist Crystals or Crystalline Powder
color 
Blue
Water Solubility 
Soluble in water.
Merck 
14,5792
BRN 
1708494
InChIKey
MBKDYNNUVRNNRF-UHFFFAOYSA-N
CAS DataBase Reference
1984-15-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 3
WGK Germany 
-
RTECS 
SZ9138000
F 
3
HazardClass 
8
PackingGroup 
III
HS Code 
29319019
Toxicity
LD50 in mice, rabbits (mg/kg): 45-50 i.v. (Subramanian, 1975)

MSDS

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METHYLENEDIPHOSPHONIC ACID Usage And Synthesis

Chemical Properties

Colourless solid

Uses

Radioactive imaging agent

Uses

Methylenediphosphonic acid is a radioactive compound used for skeletal imaging. MDP has been used as a chelating agent to vary calcium levels in cell culture in a study of caffeine storage in bovine chromaffin cells.

Uses

Methylenediphosphonic acid can be used as a precursor in the synthesis of:

  • Mesoporous aluminum organophosphonate in the presence of alkyltrimethylammonium as a surfactant.
  • Tetraester of methylenediphosphonic acids which are used as metal ion extractants for actinides in all oxidation states.

Definition

ChEBI: A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups.

General Description

MDP (Methylenediphosphonic acid) is a phosphonic analog of ATP.

METHYLENEDIPHOSPHONIC ACID Preparation Products And Raw materials

Raw materials

Hydrochloric acidTetraisopropyl methylenediphosphonate

Preparation Products

Tiludronic acid

METHYLENEDIPHOSPHONIC ACIDSupplier

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