Monomethyl adipate Chemical Properties

Melting point:

7-9 °C (lit.)

Boiling point:

162 °C/10 mmHg (lit.)

Density 

1.081 g/mL at 25 °C (lit.)

vapor pressure 

1.48Pa at 25℃

refractive index 

n20/D 1.441(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Liquid

pka

4.69±0.10(Predicted)

color 

Clear colorless

Water Solubility 

Not miscible or difficult to mix with water.

BRN 

1766411

LogP

0.500 (est)

CAS DataBase Reference

627-91-8(CAS DataBase Reference)

NIST Chemistry Reference

Hexanedioic acid, monomethyl ester(627-91-8)

EPA Substance Registry System

Monomethyl adipate (627-91-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

TSCA 

Yes

HS Code 

29171290

MSDS

• Language:English Provider:Monomethyl adipate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Monomethyl adipate Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Methyl hydrogen adipate is a useful synthetic intermediate. It can be used to prepare 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors which show potential antitumor activities. It can be also used to synthesize mannose-linked biphenylylacetic acid derivatives as novel inhibitors of selectin-mediated cell adhesion.

Definition

ChEBI: Monomethyl adipate is a dicarboxylic acid monoester that is the monomethyl ester of adipic acid. It has a role as a metabolite and a plasticiser.

Synthesis

According to the general procedure described above, a has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 80%.
The synthetic method of Monomethyl adipate mainly contains following three kinds:
The one, under alkaline condition or issue the first portion hydrolysis reaction in the catalysis of bioactive enzyme (pork liver lipase etc.) and obtain Monomethyl adipate (such as document Blaise; Koehler; Bulletin de la Societe Chimique deFrance; Vol. (4) 7; (1910); P.219).
The 2nd, by hexanodioic acid or adipic anhydride and ethanol, as catalyzer, the control reaction conditions carries out esterification and obtains Monomethyl adipate (such as document Chem.Zentralbl. with acid; Vol.97; (1926; P.126));
The 3rd, by the people such as Swann nineteen forty-three with hexanodioic acid, diethylene adipate and ethanol with the condition of acid as catalyst under control reaction conditions obtain monomethyl adipate(document such as Swann; Oehler; Buswell; Org.synth.Coll.Vol.11; (1943); P.227).
Synthetic method of monomethyl adipate
http://www.orgsyn.org/demo.aspx?prep=CV2P0264

Monomethyl adipate(627-91-8)Related Product Information

• Dimethyl adipate
• Thiophanate-methyl
• Diethyl adipate
• Monoethyl Adipate
• Kresoxim-methyl
• Methyl acrylate
• Bis(2-ethylhexyl) adipate
• Ammonium adipate
• BUTYL OLEATE
• Methylparaben
• Bensulfuron methyl
• POLY(1 6-HEXAMETHYLENE ADIPATE) AVERAG&
• Tris(trimethylsilyl)phosphate
• SPIRAMYCIN ADIPATE
• METHYL THIOPHENE-2-CARBOXYLATE
• Adipic dihydrazide
• Adipic acid
• Lipase