Albiflorin
Albiflorin Basic information
- Product Name:
- Albiflorin
- Synonyms:
-
- (1R,3R,4R,6S,9S)-9-[(Benzoyloxy)Methyl]-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-Methyl-7-oxatricyclo[4.3.0.03,9]nonan-8-one
- Albiflorin, froM Paeonia lactiflora
- ALBIFLORIN
- Albiflorin 9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one
- Albiflorin std
- 9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one
- [(benzoyloxy)methyl]-1-(β-D-glucopyranosyloxy)-
- 4-hydroxy-6-methyl-, (1R, 3R, 4R, 6S)-
- CAS:
- 39011-90-0
- MF:
- C23H28O11
- MW:
- 480.46
- Product Categories:
-
- The group of Paeoniflorin
- Miscellaneous Natural Products
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 39011-90-0.mol
Albiflorin Chemical Properties
- Boiling point:
- 722.1±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- pka
- 12.84±0.70(Predicted)
- form
- powder
- color
- White
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29389090
Albiflorin Usage And Synthesis
Definition
ChEBI: Albiflorin is a monoterpene glycoside with formula C23H28O11, originally isolated from the roots of Paeonia lactiflora. It has a role as a plant metabolite and a neuroprotective agent. It is a benzoate ester, a gamma-lactone, a beta-D-glucoside, a monoterpene glycoside, a secondary alcohol and a bridged compound.
Biological Functions
Albiflorin is a natural product isolated from Paeoniae Radix. It enhances mitochondrial function to suppress antimycin A-induced oxidative damage via the preservation of cytochrome c and cardiolipin. Also it may reduce or prevent osteoblast degeneration in osteoporosis.
Biological Activity
Albiflorin is a natural phenolic compound that has been shown to be an inhibitor of toll-like receptor (TLR) 4.
in vitro
Albiflorin can modulate the TLR-induced inflammatory response by inhibiting the production of proinflammatory cytokines, such as IL-6, IL-8, and TNF-α. This compound also inhibits matrix metalloproteinase activity in tubulointerstitial injury, leading to decreased interstitial inflammation and proteinuria. Albiflorin has been shown to be effective at low doses in experimental models of rheumatoid arthritis. It is believed that this effect may be due to its ability to inhibit TLR4 expression or activation.
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