1-Boc-3-hydroxymethyl-piperazine Chemical Properties

Melting point:

93.0 to 97.0 °C

Boiling point:

322.9±22.0 °C(Predicted)

Density 

1.085±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

14.97±0.10(Predicted)

color 

White to Almost white

CAS DataBase Reference

301673-16-5(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2939800000

1-Boc-3-hydroxymethyl-piperazine Usage And Synthesis

Uses

1-Boc-3-Hydroxymethylpiperazine is an organic compound commonly used as an organic synthesis intermediate and pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 1-BOC-3-hydroxymethylpiperazine from 1,4-bis(Boc)-2-piperazinemethanol: To a solution of di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (4.00 g, 12.6 mmol) in ethanol (110 ml) was added sodium hydroxide (1.99 g, 49.8 mmol), and the mixture was heated under reflux conditions for 16 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was poured into water and the mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the target product 1-BOC-3-hydroxymethylpiperazine (2.71 g, 99.6% yield) as a solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 1.46 (9H, s), 2.12 (1H, br s), 2.64-3.01 (6H, br s), 3.47-3.53 (1H, m), 3.62-3.67 (1H, m), 3.89 (2H, br s).

References

[1] Patent: US2009/318412, 2009, A1. Location in patent: Page/Page column 34-35
[2] Patent: EP1338595, 2003, A2

1-Boc-3-hydroxymethyl-piperazine(301673-16-5)Related Product Information

• 1-Boc-3-hydroxymethylpyrrolidine
• tert-butyl 3-(cyanoMethyl)piperidine-1-carboxylate
• 1-Boc-3-(Aminomethyl)azetidine
• (R)-1-BOC-3-(Hydroxymethyl)piperazine
• (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID
• 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
• N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID
• 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
• N-4-Boc-2-piperazinecarboxylic acid
• METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE
• (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
• 4-Boc-1-Fmoc-2-piperazinecarboxylic acid
• METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE
• (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID
• (R)-1-N-Boc-2-(hydroxymethyl)piperazine
• (S)-1-Boc-2-Hydroxymethyl-piperazine
• 1-N-Boc-2-(hydroxymethyl)piperazine