ACETYL COENZYME A TRILITHIUM SALT
ACETYL COENZYME A TRILITHIUM SALT Basic information
- Product Name:
- ACETYL COENZYME A TRILITHIUM SALT
- Synonyms:
-
- ACETYL-S-COA LI3
- ACETYL-COENZYME A, TRILITHIUM
- ACETYL COENZYME A TRILITHIUM SALT
- ACETYL COENZYME A, LITHIUM
- ACETYL COENZYME A LITHIUM SALT
- ACETYL-COA TRILITHIUM SALT
- ACETYL-COA LI3
- C2:0
- CAS:
- 75520-41-1
- MF:
- C23H39LiN7O17P3S
- MW:
- 817.52
- EINECS:
- 278-233-4
- Mol File:
- 75520-41-1.mol
ACETYL COENZYME A TRILITHIUM SALT Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in water (10 mg/ml)
- form
- solid
- color
- White
- Stability:
- Stable for 2 years as supplied. Solutions in water may be stored at -20°C for up to 2 weeks.
MSDS
- Language:English Provider:SigmaAldrich
ACETYL COENZYME A TRILITHIUM SALT Usage And Synthesis
Description
Acetyl-CoA (75520-41-1) is an essential cofactor for cellular metabolism, being an ‘activated acetate’ that shuttles its moieties back and forth during anabolic, catabolic, and metabolic processes involving fundamental molecules: fatty acids, amino acids, glucose, and ATP.1 In the laboratory, it can be used as a substrate in chloramphenicol acetyltransferase (CAT) transcription reporter assays2 or in histone acetyltransferase (HAT) assays in epigenetics research3.
Chemical Properties
White amorphous powder
Uses
Acetyl Coenzyme?A Lithium Salt is an important molecule in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to acyl carrier proteins and formyltetrahydrofolate dehydrogenase.
in vivo
Acetyl coenzyme A trilithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3]. Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A concentrations in the brain and actually increase hepatic Acetyl coenzyme A and protein acetylation levels[4].
References
[1] WOLFE A J. The acetate switch.[J]. Microbiology and molecular biology reviews : MMBR, 2005: 12-50. DOI:10.1128/mmbr.69.1.12-50.2005
[2] C M GORMAN B H H L F Moffat. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.[J]. Molecular and Cellular Biology, 1982, 2 9: 1044-1051. DOI:10.1128/mcb.2.9.1044-1051.1982
[3] YOUNGJOO KIM John M D Kirk G Tanner. A Continuous, Nonradioactive Assay for Histone Acetyltransferases[J]. Analytical biochemistry, 2000, 280 2: Pages 308-314. DOI:10.1006/abio.2000.4546
ACETYL COENZYME A TRILITHIUM SALTSupplier
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 4009903999 13355009207
- 3007715519@qq.com
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
- Tel
- 400 638 7771
- sales@heowns.com
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
ACETYL COENZYME A TRILITHIUM SALT(75520-41-1)Related Product Information
- ACETYL COENZYME A (C2:0) LITHIUM
- LAUROYL COENZYME A C12:0 LITHIUM SALT
- N-HEXANOYL COENZYME A LITHIUM SALT (C6:0)
- Lithium
- METHYLMALONYL COENZYME A LITHIUM
- ACETYL COENZYME A TRILITHIUM SALT
- COENZYME A TRILITHIUM SALT
- N-OCTADECANOYL COENZYME A LITHIUM SALT
- ARACHIDONOYL COENZYME A (C20:4) LITHIUM SALT
- CIS-9-OCTADECENOYL COENZYME A LITHIUM SALT
- ACETYL COENZYME A TRILITHIUM SALT TRIHYDRATE
- N-HEXADECANOYL COENZYME A LITHIUM SALT
- MYRISTOYL COENZYME A C14:0 LITHIUM SALT
- N-BUTYRYL COENZYME A, LITHIUM
- PROPIONYL COENZYME A, LI SALT
- CAPROYL COENZYME A TRILITHIUM SALT
- DODECANOYL-COENZYME A LITHIUM SALT
- LINOLEOYL COENZYME A (C18:2) LITHIUM SALT