MYRISTOYL COENZYME A C14:0 LITHIUM SALT Chemical Properties

storage temp. 

-20°C

form 

Solid

color 

White to off-white

Safety Information

WGK Germany 

3

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich

MYRISTOYL COENZYME A C14:0 LITHIUM SALT Usage And Synthesis

Uses

Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Biochem/physiol Actions

Myristoyl coenzyme A is a combination of coenzyme A and myristate. It serves as a substrate in protein myristoylation, catalyzed by the enzyme N-myristoyl transferase. Myristyolation involves the transfer of the myristoyl group to the glycine residue at the amino-terminal of the protein.

IC 50

Human Endogenous Metabolite

References

[1] Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158(2):107-13. DOI:10.1007/BF00225835

MYRISTOYL COENZYME A C14:0 LITHIUM SALT(187100-75-0)Related Product Information

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