3'-DEPHOSPHOCOENZYME A
3'-DEPHOSPHOCOENZYME A Basic information
- Product Name:
- 3'-DEPHOSPHOCOENZYME A
- Synonyms:
-
- 3'-DEPHOSPHOCOENZYME A
- 3'-DEPHOSPHOCOENZYME A FREE ACID
- [5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]-phosphoryl]oxy-phosphinic acid
- Dephospho-CoA
- dephosphocoenzyme A
- 3'-dephospho-CoA
- Coenzyme A, 3'-O-dephosphono-
- 3'-Dephosphocoenzyme A >=90% (HPLC)
- CAS:
- 3633-59-8
- MF:
- C21H35N7O13P2S
- MW:
- 687.55
- Product Categories:
-
- Acyl Transfer ReagentsMetabolic Pathways
- Lipid LibraryMetabolites and Cofactors on the Metabolic Pathways Chart
- LipidMetabolomics
- Cofactor
- Cofactors
- Enzymes, Inhibitors, and Substrates
- Metabolic Libraries
- Metabolites and Cofactors on the Metabolic Pathways Chart
- Pantothenate
- Pharmaceutical
- Mol File:
- 3633-59-8.mol
3'-DEPHOSPHOCOENZYME A Chemical Properties
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Water: 50 mg/ml
- form
- A crystalline solid
- pka
- 1.16±0.50(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
3'-DEPHOSPHOCOENZYME A Usage And Synthesis
Description
3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B5; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.
Uses
Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.
Definition
ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis
Biochem/physiol Actions
3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.
3'-DEPHOSPHOCOENZYME ASupplier
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