MY-5445
MY-5445 Basic information
- Product Name:
- MY-5445
- Synonyms:
-
- MY-5445
- 1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE
- 1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE
- N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
- N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
- MY 5445;MY5445
- 1-(3-Chloroanilino)-4-phenylphthalazine >
- aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
- CAS:
- 78351-75-4
- MF:
- C20H14ClN3
- MW:
- 331.8
- Product Categories:
-
- Cyclic Nucleotide related
- Mol File:
- 78351-75-4.mol
MY-5445 Chemical Properties
- Boiling point:
- 539.7±50.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
- pka
- 4.91±0.30(Predicted)
- form
- Yellow solid.
- color
- White to Light yellow
MY-5445 Usage And Synthesis
Description
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM.
Uses
MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.
Definition
ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.
Biological Activity
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).
in vivo
MY-5445 (0.5-3 mg/kg; i.p.; twice a day; for 15 days) produces a significant relief of mechanical hypersensitivity[3].
| Animal Model: | C57BL/6J male mice[3] |
| Dosage: | 0.5 mg/kg, 3 mg/kg |
| Administration: | Intraperitoneal injection, twice a day, for 15 days |
| Result: | Alleviated the cuff-induced allodynia. |
IC 50
PDE5: 1.3 μM (Ki); PDE5: 6.7 μM (IC50); PDE4: 37 μM (IC50)
References
[1] JOHN E. SOUNESS. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine[J]. British Journal of Pharmacology, 1989, 98 3: 725-734. DOI: 10.1111/j.1476-5381.1989.tb14599.x
[2] T YAMAMOTO. Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.[J]. The Journal of Biological Chemistry, 1983, 258 23: 14173-14177.
MY-5445Supplier
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MY-5445(78351-75-4)Related Product Information
- ZARDAVERINE
- RO 20-1724
- BRL 50481
- Vinpocetine
- ZAPRINAST
- ROLIPRAM
- Cilostazol
- (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
- CILOSTAMIDE
- EHNA HYDROCHLORIDE
- 3-AMINO-6-METHYLPYRIDAZINE
- AKOS BB-5445
- 3-AMINO-6-PHENYLPYRIDAZINE
- MY-5445
- 1-AMINOPHTHALAZINE
- RARECHEM AK PP 5445
- AURORA KA-5445
- AURORA 5445