MY-5445 Chemical Properties

Boiling point:

539.7±50.0 °C(Predicted)

Density 

1.310±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml

pka

4.91±0.30(Predicted)

form 

Yellow solid.

color 

White to Light yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2933.99.8290

MY-5445 Usage And Synthesis

Description

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a K_i value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with K_i values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC₅₀ value of 4 μM.

Uses

MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.

Definition

ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).

MY-5445(78351-75-4)Related Product Information

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