4-Fluorophenyl sulfone Chemical Properties

Melting point:

98-100 °C(lit.)

Boiling point:

367.9±27.0 °C(Predicted)

Density 

1.3538 (estimate)

storage temp. 

Store below +30°C.

solubility 

soluble in Methanol

form 

Crystals or Powder

color 

White to brown

BRN 

1970911

InChI

InChI=1S/C12H8F2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H

InChIKey

PLVUIVUKKJTSDM-UHFFFAOYSA-N

SMILES

S(C1=CC=C(F)C=C1)(C1=CC=C(F)C=C1)(=O)=O

CAS DataBase Reference

383-29-9(CAS DataBase Reference)

NIST Chemistry Reference

Sulfone, bis(4-fluorophenyl)-(383-29-9)

EPA Substance Registry System

Benzene, 1,1'-sulfonylbis[4-fluoro- (383-29-9)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29309070

MSDS

• Language:English Provider:4-Fluorophenyl sulfone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Fluorophenyl sulfone Usage And Synthesis

Chemical Properties

white to brown crystals or powder

Uses

4-Fluorophenylsulfone was used in substitution reactions with deprotonated amines.

Synthesis

GENERAL PROCEDURE: A mixture of sodium aryl sulfite (1 mmol), copper(II) acetate (0.5 mmol) and acetonitrile (1 mL) was stirred in air at 60°C for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through filter paper. Subsequently, the organic phase was evaporated under reduced pressure and the residue was purified by fast column chromatography (silica gel, eluent ethyl acetate/petroleum ether=1/10) to afford the target product 4,4'-difluorodiphenyl sulfone. All products were known compounds and their structures were confirmed by 1H NMR, 13C NMR and high resolution mass spectrometry (HRMS).

References

[1] Journal of Chemical Research, 2014, vol. 38, # 5, p. 265 - 268

4-Fluorophenyl sulfone(383-29-9)Related Product Information

• 4,4'-Diaminodiphenylsulfone
• Florfenicol
• Diphenyl sulfone
• (Trifluoromethoxy)benzene
• 3-(Trifluoromethyl)benzaldehyde
• Tetradifon
• Dimethyl sulfoxide
• 4-FLUORO DIPHENYL SULFIDE
• Thiophenol
• Phenyl sulfoxide
• Dimethyl sulfone
• METHYL PHENYL SULFOXIDE
• Methyl phenyl sulfone
• Dimethyl sulfide
• Diphenyl sulfide
• Hydrogen Sulfide
• 4-Fluorothiophenol
• Sulfur dioxide