4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Chemical Properties

Melting point:

>270°C (dec.)

Boiling point:

701.1±60.0 °C(Predicted)

Density 

1.561±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

3.77±0.30(Predicted)

form 

Solid

color 

Pale Yellow

Stability:

Hygroscopic

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Usage And Synthesis

Uses

Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).

Definition

ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.

Biological Activity

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT(153436-22-7)Related Product Information

• 4-CHLORO-1H-INDOLE-2-CARBALDEHYDE
• 6-CHLORO-2-METHYLINDOLE
• 6-CHLORO-1H-INDOLE-2-CARBALDEHYDE
• 4-chloro-1H-indole-2-carboxylic acid
• 6-Chloroindole-2-carboxylic acid
• 4,6-DICHLORO-2-METHYLINDOLE
• 4-CHLORO-2-METHYL-1H-INDOLE
• (6-CHLORO-1H-INDOL-2-YL)-METHANOL
• 4,6-Dichloro-1H-indole-2-carboxylic acid
• 4,6-Dichloro-1H-indole
• 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT