N-Acetyl-L-leucine CAS#: 1188-21-2

N-Acetyl-L-leucine Basic information

Product Name:

N-Acetyl-L-leucine

Synonyms:

AKOS BBS-00004735
ACETYL-DL-LEUCINE, N-
ACETYL-DL-LEUCINE
ACETYL-L-LEUCINE
AC-DL-LEU-OH
AC-LEUCINE
AC-LEU-OH
IFLAB-BB F0777-0821

CAS:

1188-21-2

MF:

C8H15NO3

MW:

173.21

EINECS:

214-706-3

Product Categories:

N-Acetyl-Amino acid series
Amino Acid Derivatives
Leucine
Peptide Synthesis
Leucine [Leu, L]
Amino Acids and Derivatives
Ac-Amino Acids
Amino Acids (N-Protected)
Biochemistry
Amino Acid Derivatives
Amino Acids
Amino Acids Derivatives
amino acid
amino
bc0001
1188-21-2

Mol File:

1188-21-2.mol

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N-Acetyl-L-leucine Chemical Properties

Melting point:: 187-190 °C(lit.)
alpha: -24.5 º (c=4, MeOH)
Boiling point:: 303.86°C (rough estimate)
Density: 1.1599 (rough estimate)
refractive index: -22 ° (C=5, EtOH)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form: Crystalline Powder
pka: 3.67±0.10(Predicted)
color: White
optical activity: [α]25/D 23±3°, c = 2 in ethanol
Water Solubility: 0.81 g/100 mL (20 ºC)
BRN: 1724849
CAS DataBase Reference: 1188-21-2(CAS DataBase Reference)
NIST Chemistry Reference: L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System: L-Leucine, N-acetyl- (1188-21-2)

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29241900

MSDS

Language:English Provider:SigmaAldrich
Language:English Provider:ACROS
Language:English Provider:ALFA

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N-Acetyl-L-leucine Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].

Animal Model:	Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL^[3]
Dosage:	60 mg/kg
Administration:	i.v., 15 days
Result:	Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.

Animal Model:	C57/BL6 mice^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 1-28 days
Result:	Did not afect food intake and body weight in mice.

Animal Model:	N-Acetyl-L-leucine-treated TBI mouse cortices^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 28 days
Result:	Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.

IC 50

Human Endogenous Metabolite

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

Sodium hydroxide Methanol Acetic anhydride L-Leucine

N-Acetyl-L-leucineSupplier

Shanghai Jizhi Biochemical Technology Co. Ltd. Gold

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