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N-Acetyl-L-leucine

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N-Acetyl-L-leucine Basic information

Product Name:
N-Acetyl-L-leucine
Synonyms:
  • AKOS BBS-00004735
  • ACETYL-DL-LEUCINE, N-
  • ACETYL-DL-LEUCINE
  • ACETYL-L-LEUCINE
  • AC-DL-LEU-OH
  • AC-LEUCINE
  • AC-LEU-OH
  • IFLAB-BB F0777-0821
CAS:
1188-21-2
MF:
C8H15NO3
MW:
173.21
EINECS:
214-706-3
Product Categories:
  • N-Acetyl-Amino acid series
  • Amino Acid Derivatives
  • Leucine [Leu, L]
  • Amino Acids and Derivatives
  • Leucine
  • Peptide Synthesis
  • Amino Acids Derivatives
  • Amino Acid Derivatives
  • Amino Acids
  • Ac-Amino Acids
  • Amino Acids (N-Protected)
  • Biochemistry
  • amino acid
  • amino
  • bc0001
  • 1188-21-2
Mol File:
1188-21-2.mol
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N-Acetyl-L-leucine Chemical Properties

Melting point:
187-190 °C(lit.)
alpha 
-24.5 º (c=4, MeOH)
Boiling point:
303.86°C (rough estimate)
Density 
1.1599 (rough estimate)
refractive index 
-22 ° (C=5, EtOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form 
Crystalline Powder
pka
3.67±0.10(Predicted)
color 
White
optical activity
[α]25/D 23±3°, c = 2 in ethanol
Water Solubility 
0.81 g/100 mL (20 ºC)
BRN 
1724849
CAS DataBase Reference
1188-21-2(CAS DataBase Reference)
NIST Chemistry Reference
L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System
L-Leucine, N-acetyl- (1188-21-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29241900

MSDS

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N-Acetyl-L-leucine Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

N-Acetyl-L-leucineSupplier

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