ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > 7-chloro-1H-indole-2-carboxylic acid
7-chloro-1H-indole-2-carboxylic acid
7-chloro-1H-indole-2-carboxylic acid Basic information
- Product Name:
- 7-chloro-1H-indole-2-carboxylic acid
- Synonyms:
-
- 7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE)
- 7-Chloroindole-2-carboxylic acid
- 1H-Indole-2-carboxylic acid, 7-chloro-
- CAS:
- 28899-75-4
- MF:
- C9H6ClNO2
- MW:
- 195.6
- EINECS:
- 249-296-5
- Mol File:
- 28899-75-4.mol
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7-chloro-1H-indole-2-carboxylic acid Chemical Properties
- Boiling point:
- 449.7±25.0 °C(Predicted)
- Density
- 1.548±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.23±0.30(Predicted)
- InChI
- InChI=1S/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13)
- InChIKey
- NVKAHBFPKVINGE-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2Cl)C=C1C(O)=O
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7-chloro-1H-indole-2-carboxylic acid Usage And Synthesis
Uses
7-chloro-1H-indole-2-carboxylic acid is an important pharmaceutical intermediate compound used in the preparation of protease inhibitors.
Synthesis
A mixture of 111.5 g of 7-chloroindole-2-carboxylate in 31.25 g of 96percent sodium hydroxide in 183 ml of methanol and 183 ml of water were heated under reflux for 1 hour, cooled to 45 ° C, and 10 percent hydrochloric acid was added dropwise to a pH of 3 to 4. The mixture was sufficiently cooled to obtain 89.7 g of product as an off-white 7-chloro-1H-indole-2-carboxylic acid.
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7-chloro-1H-indole-2-carboxylic acid(28899-75-4)Related Product Information
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