2,6-Dimethylbenzylamine Chemical Properties

Boiling point:

96-98 °C

Density 

0.952±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

9.42±0.10(Predicted)

form 

liquid

color 

Clear, colourless to very faint yellow

Safety Information

HS Code 

2921490090

2,6-Dimethylbenzylamine Usage And Synthesis

Uses

2,5-Dimethylbenzylamine is an intermediate in the synthesis of flavin derivatives for therapeutic use as anti-infective agents.

Uses

2,6-Dimethylbenzylamine is an intermediate in the synthesis of flavin derivatives for therapeutic use as anti-infective agents.

Synthesis

The general procedure for the synthesis of 2,6-dimethylbenzylamine from 2,6-dimethylbenzonitrile is as follows: Example 1: The synthetic scheme for the preparation of 2-{2-[1-(2,6-dimethylbenzyl)-6-fluoro-1H-benzimidazol-2-yl]-5-methoxy-3-methylphenoxy}acetamide ("A1") is as follows: 1.1 2,6-dimethylbenzonitrile ("1") was dissolved in a mixed solution of methanol and 10% ammonia, and the hydrogenation reaction was carried out at 5 bar hydrogen pressure and 50°C for 16 hours using nickel Nguyenne as a catalyst. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the solvent was subsequently removed under vacuum to give the product "2" as an oil in quantitative yield.Results of LC-MS analysis: retention time 1.307 min, m/e 136.5 (M+H+).

References

[1] Patent: US2010/16372, 2010, A1. Location in patent: Page/Page column 12
[2] Journal of the American Chemical Society, 1957, vol. 79, p. 4229,4230
[3] Journal of Organic Chemistry, 1958, vol. 23, p. 865,869
[4] Journal of the American Chemical Society, vol. 79, p. 6282
[5] Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, 1965, vol. 343, # 1, p. 52 - 60

2,6-Dimethylbenzylamine(74788-82-2)Related Product Information

• DL-ALPHA-METHYLBENZYLAMINE
• Phenoxybenzamine hydrochloride
• N,N-Dimethylbenzylamine (BDMA),Dimethylbenzylamine,98%,N,N-Dimethylbenzylamine
• 4-Methoxybenzylamine
• 4-Fluorobenzylamine
• Trimethoprim
• 4-Cyanobenzylamine
• N-Methylbenzylamine
• 4-(Aminomethyl)benzoic acid
• 4-(Trifluoromethyl)benzylamine
• 4-tert-Butylbenzylamine
• 4-Methylbenzylamine
• (+)-BULBOCAPNINE
• APOMORPHINE HYDROCHLORIDE
• N-Methyl-N-(4-methylbenzyl)amine
• 2-DIMETHYLAMINOMETHYLPHENOL
• 4-AMINO-N,N-DIMETHYLBENZYLAMINE
• S(+)-APOMORPHINE HYDROCHLORIDE HYDRATE