ChemicalBook > CAS DataBase List > 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE

7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE

Product Name: 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE
CAS No.: 321-50-6
Chemical Name: 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE
Synonyms: 7-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;FLUOROBENZOXAZINEDIONE;7-Fluoroisatoic anhydride;7-fluoro-1H-3,1-benzoxazine-2,4-dione;7-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE;7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-fluoro-;7-fluoro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;7-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione
CBNumber: CB01010947
Molecular Formula: C8H4FNO3
Formula Weight: 181.12
MOL File: 321-50-6.mol

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7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Property

Melting point:: 229-231 °C (decomp)
Density: 1.502±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.91±0.20(Predicted)
form: crystalline needles
color: Cream/fawn

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F592028
Product name: 4-Fluoroisatoicanhydride
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F592028
Product name: 4-Fluoroisatoicanhydride
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: PC8702
Product name: 4-Fluoroisatoicanhydride
Packaging: 5g
Price: $196
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H26-3-03
Product name: 7-Fluoroisatoic anhydride
Packaging: 5G
Price: $216
Updated: 2021/12/16

Apolloscientific

Product number: PC8702
Product name: 4-Fluoroisatoicanhydride
Packaging: 1g
Price: $85
Updated: 2021/12/16

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7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Chemical Properties,Usage,Production

Synthesis

32315-10-9

446-32-2

321-50-6

Step A- Synthesis of intermediate compound Int-4a: To a solution of 2-amino-4-fluorobenzoic acid (15.5 g, 100 mmol) in tetrahydrofuran (THF, 200 mL) was slowly added triphosgene (27.9 g, 105 mmol) at 0 °C. The reaction mixture was warmed up to 50 °C with continuous stirring for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting crude product was ground with a solvent mixture of ethyl acetate/petroleum ether (1:1, v/v) and the solid was collected by filtration to afford the intermediate compound Int-4a (15.7 g, 85% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.9 (s, 1H), 7.95-7.98 (m, 1H), 7.06-7.11 (m, 1H), 6.84-6.89 (m, 1H).

References

[1] Patent: WO2014/11769, 2014, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/8636, 2014, A1. Location in patent: Page/Page column 35
[3] Patent: US2015/203512, 2015, A1. Location in patent: Paragraph 0191; 0192
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 3, p. 971 - 983
[5] Patent: WO2010/79431, 2010, A2. Location in patent: Page/Page column 47-49

7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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321-50-6, 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONERelated Search:

7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE Benzothiazole Dibenzothiophene Thianaphthene 7-FLUORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE 7-Fluorooxindole NISTC4590527 7-FLUORO-1H-INDOL-3-METHYLAMINE Ethyl 2-(7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 7-Fluoro-3-iodo-1H-indazole 7-FLUORO-2-METHYLISATOIC ANHYDRIDE Isatoic Anhydride 2-Amino-4-fluorobenzoic acid 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE 2-AMINO-4-FLUOROBENZYL ALCOHOL 6,7-DIFLUOROISATOIC ANHYDRIDE

7-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE

7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione

2H-3,1-Benzoxazine-2,4(1H)-dione, 7-fluoro-

7-Fluoroisatoic anhydride

7-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione

7-fluoro-1H-3,1-benzoxazine-2,4-dione

FLUOROBENZOXAZINEDIONE

7-fluoro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione

7-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

321-50-6