7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE
- Product Name
- 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE
- CAS No.
- 321-50-6
- Chemical Name
- 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE
- Synonyms
- 7-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;FLUOROBENZOXAZINEDIONE;7-Fluoroisatoic anhydride;7-fluoro-1H-3,1-benzoxazine-2,4-dione;7-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE;7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-fluoro-;7-fluoro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;7-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione
- CBNumber
- CB01010947
- Molecular Formula
- C8H4FNO3
- Formula Weight
- 181.12
- MOL File
- 321-50-6.mol
7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Property
- Melting point:
- 229-231 °C (decomp)
- Density
- 1.502±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.91±0.20(Predicted)
- form
- crystalline needles
- color
- Cream/fawn
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F592028
- Product name
- 4-Fluoroisatoicanhydride
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F592028
- Product name
- 4-Fluoroisatoicanhydride
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- PC8702
- Product name
- 4-Fluoroisatoicanhydride
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 4H26-3-03
- Product name
- 7-Fluoroisatoic anhydride
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 056345
- Product name
- 7-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Chemical Properties,Usage,Production
Synthesis
32315-10-9
446-32-2
321-50-6
Step A- Synthesis of intermediate compound Int-4a: To a solution of 2-amino-4-fluorobenzoic acid (15.5 g, 100 mmol) in tetrahydrofuran (THF, 200 mL) was slowly added triphosgene (27.9 g, 105 mmol) at 0 °C. The reaction mixture was warmed up to 50 °C with continuous stirring for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting crude product was ground with a solvent mixture of ethyl acetate/petroleum ether (1:1, v/v) and the solid was collected by filtration to afford the intermediate compound Int-4a (15.7 g, 85% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.9 (s, 1H), 7.95-7.98 (m, 1H), 7.06-7.11 (m, 1H), 6.84-6.89 (m, 1H).
References
[1] Patent: WO2014/11769, 2014, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/8636, 2014, A1. Location in patent: Page/Page column 35
[3] Patent: US2015/203512, 2015, A1. Location in patent: Paragraph 0191; 0192
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 3, p. 971 - 983
[5] Patent: WO2010/79431, 2010, A2. Location in patent: Page/Page column 47-49
7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE Suppliers
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- Country
- India
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