2-Methyl-2-propyl-1,3-propanediol

Synthesis

Product Name: 2-Methyl-2-propyl-1,3-propanediol
CAS No.: 78-26-2
Chemical Name: 2-Methyl-2-propyl-1,3-propanediol
Synonyms: DURANOL;NSC 26233;Dimethylolpentane,97%;Pentane-2,2-dimethanol;2,2-DIMETHYLOL-PENTANE;Carisoprodol iMpurity C;Carisoprodol EP Impurity C;Carisoprodol intermediate H;2,2-BIS(HYDROXYMETHYL)PENTANE;2-methyl-2-propyl-3-propanediol
CBNumber: CB0114707
Molecular Formula: C7H16O2
Formula Weight: 132.2
MOL File: 78-26-2.mol

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2-Methyl-2-propyl-1,3-propanediol Property

Melting point:: 57-59 °C (lit.)
Boiling point:: 230 °C/753 mmHg (lit.)
Density: 0.9744 (rough estimate)
refractive index: 1.4474 (estimate)
Flash point:: >230 °F
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.57±0.10(Predicted)
form: Solid
color: White
BRN: 1734432
CAS DataBase Reference: 78-26-2(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Propanediol, 2-methyl-2-propyl-(78-26-2)
EPA Substance Registry System: 1,3-Propanediol, 2-methyl-2-propyl- (78-26-2)

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Safety

Hazard Codes: Xn
Risk Statements: 36-22
Safety Statements: 22-24/25-39-26
WGK Germany: 1
RTECS: TY9386000
HS Code: 2905399590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M75209
Product name: 2-Methyl-2-propyl-1,3-propanediol
Purity: 98%
Packaging: 25g
Price: $46.8
Updated: 2024/03/01

TCI Chemical

Product number: D0766
Product name: 2-Methyl-2-propyl-1,3-propanediol
Purity: >98.0%(GC)
Packaging: 25g
Price: $23
Updated: 2024/03/01

TCI Chemical

Product number: D0766
Product name: 2-Methyl-2-propyl-1,3-propanediol
Purity: >98.0%(GC)
Packaging: 500g
Price: $218
Updated: 2024/03/01

Usbiological

Product number: 282563
Product name: 2-Methyl-2-propyl-1,3-propanediol
Packaging: 25g
Price: $292
Updated: 2021/12/16

TRC

Product number: M320590
Product name: 2-Methyl-2-propyl-1,3-propanediol
Packaging: 250g
Price: $155
Updated: 2021/12/16

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2-Methyl-2-propyl-1,3-propanediol Chemical Properties,Usage,Production

Synthesis

2-Methyl-2-pentenal was hydrogenated at 100°C and 1.3-1.5MPa with a yield of 80%. After obtaining 2-methylpentenal, it was added to 36% formaldehyde, and the reaction was carried out at room temperature. Sodium hydroxide solution was added dropwise. The reaction was exothermic, and the temperature was naturally raised to 70 °C, then heated to 90 °C, added for 1 h, cooled to 60 °C and left to separate layers. The upper layer was washed with water, the washings were combined with the lower layer, and extracted with benzene. The extract and the upper layer were combined, and benzene was recovered by distillation, followed by distillation under reduced pressure to collect a fraction at 160°C (14.7kPa), which was 2-methyl-2-propyl-1,3-propanediol,yield 93%.

Description

2-Methyl-2-propyl-1,3-propanediol is produced either by the salt-free procedure based on aldol addition followed by hydrogenation or by the classical combination of hydroxymethylation and Cannizzaro-type disproportionation with formaldehyde. The production costs are considerably higher than for neopentyl glycol, because the synthesis of 2-methylpentanal from propanal requires two additional steps: aldol condensation and hydrogenation.

Chemical Properties

Whgite Crystalline Solid

Uses

An intermediate in the synthesis of Carisoprodol.

Uses

2-Methyl-2-propyl-1,3-propanediol is mainly used in pharmaceutical applications such as production of dicarbamates. Meprobamate (2-methyl-2-propyl-1,3-propanediol dicarbamate), is used as an anxiolytic drug (tranquilizer). Carisoprodol (N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate), possesses strong centrally-acting muscle relaxant activity.

2-Methyl-2-propyl-1,3-propanediol Preparation Products And Raw materials

Raw materials

Methyl valeraldehyde

Preparation Products

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2-Methyl-2-propyl-1,3-propanediol Suppliers

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View Lastest Price from 2-Methyl-2-propyl-1,3-propanediol manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Methyl-2-Propyl-1,3-Propanediol 78-26-2
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-11

Wuhan Monad Medicine Tech Co.,LTD

Product: 2-Methyl-2-propyl-1,3-propanediol 78-26-2
Price: US $10.00/KG
Min. Order: 25Kg/Drum
Purity: 99.99%
Supply Ability: 20 tons/month
Release date: 2020-12-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Methyl-2-propyl-1,3-propanediol 78-26-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

78-26-2, 2-Methyl-2-propyl-1,3-propanediolRelated Search:

Kresoxim-methyl Basic Violet 1 Cyclopentane 2-METHYL-1,3-PROPANEDIOL Propylene glycol 1-Methoxy-2-propanol 1,3-Propanediol Acetonitrile Methanol 1-Methoxy-2-propyl acetate Methyl acrylate Pentane Tris(hydroxymethyl)nitromethane (R)-(-)-1,2-Propanediol Propyl butyrate Paraquat dichloride Cyclopropyl methyl ketone Chloromethyl isopropyl carbonate

methyl-2-propyl-2-propanediol-1,3

2-METHYL-2-PROPYL-1,3-PROPANEDIOL,99%

2-METHYL-2-PROPYL-1,3-PROPANDIOL

Carisoprodol intermediate H

NSC 26233

1,3-Propanediol, 2-methyl-2-propyl-

2-methyl-2-propyl-1,3-propandiol (intermediate of meprobamate or carisoprodol)

DURANOL

2-METHYL-2-PROPYL-1,3-PROPANEDIOL [FOR CARISOPRODOL]

1,3‐Dihydroxy‐2‐methyl‐2‐propylpropane

2-Propyl-2-methyl-1,3-propanediol

Pentane-2,2-dimethanol

2,2-Dimethylolpentane2,2-Bis(hydroxymethyl)pentane

2-Methyl-2-propyl-1,3-propanediol 98%

2-METHYL-2-PROPYL-1,3-PROPANEDIOL

2-METHYL-2-N-PROPYL-1,3-PROPANEDIOL

2,2-Bis(hydroxymethyl)pentane 2,2-Dimethylolpentane

Carisoprodol iMpurity C

2-methyl-2-propyl-3-propanediol

3-Propanediol,2-methyl-2-propyl-1

2-Methyl-2-Propylpropan-1,3-Diol

Dimethylolpentane,97%

2-methyl-2-propylpropane-1,3-diol

2,2-DIMETHYLOL-PENTANE

2,2-BIS(HYDROXYMETHYL)PENTANE

Carisoprodol EP Impurity C

2-Methyl-2-propyl-1,3-propanediol &gt

2,2-Bis(Hydroxymethyl)Pentane,>99%

78-26-2 2-Methyl-2-propyl-1,3-propanediol

Bupropion Impurity 4（Bupropion USP RC D）-d9

2-Methyl-2-propy1-1,3-propanediol

78-26-2

CH3CCH2OH2CH2CH2CH3

Organic Building Blocks

Oxygen Compounds

Polyols

Building Blocks

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

Pharmaceutical Intermediates

(intermediate of meprobamate or carisoprodol)

Intermediates & Fine Chemicals

Pharmaceuticals

Polyols