6-METHYL-2-PYRIDINEMETHANOL
- Product Name
- 6-METHYL-2-PYRIDINEMETHANOL
- CAS No.
- 1122-71-0
- Chemical Name
- 6-METHYL-2-PYRIDINEMETHANOL
- Synonyms
- RARECHEM AL BD 0183;6-METHYL-2-PYRIDINEM;6-methyl-2-pyridinemthanol;6-HYDROXYMETHYL-2-PICOLINE;6-methyl-2-pyridylmethanol;6-METHY-2-PYRIDINEMETHANOL;2-Methyl-6-pyridinemethanol;2-Methylpyridine-6-methanol;6-METHYL-2-PYRIDINEMETHANOL;6-METHYLPYRIDINE-2-CARBINOL
- CBNumber
- CB0122483
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 1122-71-0.mol
6-METHYL-2-PYRIDINEMETHANOL Property
- Melting point:
- 32-34 °C(lit.)
- Boiling point:
- 105-108 °C12 mm Hg(lit.)
- Density
- 1.0877 (rough estimate)
- refractive index
- 1.5380 (estimate)
- Flash point:
- 228 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.02±0.10(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorless to Light yellow
- Water Solubility
- Low soluble in water, high soluble in ethanol, acetic acid. Soluble in benzene, toluene.
- CAS DataBase Reference
- 1122-71-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M78607
- Product name
- 6-Methyl-2-pyridinemethanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $55
- Updated
- 2023/06/20
- Product number
- M1282
- Product name
- 6-Methyl-2-pyridinemethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- M1282
- Product name
- 6-Methyl-2-pyridinemethanol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $556
- Updated
- 2025/07/31
- Product number
- M219623
- Product name
- 6-Methyl-2-pyridinemethanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 092614
- Product name
- 6-Methyl-2-pyridinemethanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
6-METHYL-2-PYRIDINEMETHANOL Chemical Properties,Usage,Production
Chemical Properties
Clear light brown liquid or low melting solid
Uses
Use as primary and secondary intermediate.
Definition
ChEBI: 6-methyl-2-pyridinemethanol is a member of methylpyridines.
Synthesis
13287-64-4
1122-71-0
(a) glacial acetic acid was added to the reaction flask, followed by 2,6-dimethylpyridine, and heated until it was well mixed, and the mass ratio of glacial acetic acid to 2,6-dimethylpyridine was 2.5:1; (b) hydrogen peroxide and catalyst tungsten oxide were added sequentially to the reaction mixture of step (a), and the amount of tungsten oxide was added as 5% of the mass of 2,6-dimethylpyridine, and the amount of hydrogen peroxide was 2,6-dimethyl pyridine mass, and the reaction lasted for 3 hours; (c) an equal volume of 28% hydrogen peroxide was added to the reaction mixture of step (b) again, and the reaction was continued for 7 hours; (d) after the completion of the reaction, the reaction mixture was subjected to distillation under reduced pressure, and the fraction at 130-150 °C/12 mmHg was collected; (e) the fraction obtained in step (d) was refluxed with acetic anhydride at the ratio of 0.7:1 by volume, and at the end of the reaction, the reaction was allowed to proceed to the refluxing stage. Refluxing was carried out, and the glacial acetic acid was allowed to dry at the end of the reaction, after which the mother liquor was refluxed with 10% potassium hydroxide solution at the ratio of 1:3 by volume for 8 hours, and cooled to room temperature; (f) six countercurrent extractions were carried out on the reaction solution in step (e) with dichloromethane using two times the volume of dichloromethane each time, and the extracts were combined and distilled to recover the dichloromethane, to obtain 6-methyl-2-pyridine methanol. In this method, the yield of 6-methyl-2-pyridinemethanol was 94%, the reaction selectivity was 95.2%, and the purity of the final product was 99.1%, which met the requirements of the pharmaceutical industry.
References
[1] Patent: CN104610134, 2017, B. Location in patent: Paragraph 0029-0036; 0038-0045; 0047-0054; 0056-0063;
[2] Yakugaku Zasshi, 1954, vol. 74, p. 790
[3] Chem.Abstr., 1955, p. 11646
[4] Helvetica Chimica Acta, 1955, vol. 38, p. 1114,1116
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
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View Lastest Price from 6-METHYL-2-PYRIDINEMETHANOL manufacturers
- Product
- 6-METHYL-2-PYRIDINEMETHANOL 1122-71-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 6-Methyl-2-pyridinemethanol 1122-71-0
- Price
- US $0.00-0.00/G
- Min. Order
- 10G
- Purity
- 0.98
- Supply Ability
- 500kg
- Release date
- 2023-09-25
- Product
- 6-METHYL-2-PYRIDINEMETHANOL 1122-71-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25