ChemicalBook > CAS DataBase List > kauran-16,17-diol

kauran-16,17-diol

Product Name: kauran-16,17-diol
CAS No.: 16836-31-0
Chemical Name: kauran-16,17-diol
Synonyms: ent-kauran;kauran-16,17-diol;ent-kauran-16β,17-diol;ent-Kaurane-16β,17-diol;Kauran-16,17-diol/16836-31-0;kauran-16,17-diol, 10 mM in DMSO;Kauran-16,17-diol (ent-Kauran-16beta,17-diol);inhibit,Inhibitor,Apoptosis,kauran16,17diol,kauran 16,17 diol;(4aR,6aS,8R,9S,11aR,11bR)-8-(Hydroxymethyl)-4,4,11b-trimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalen-8-ol
CBNumber: CB01308437
Molecular Formula: C20H34O2
Formula Weight: 306.48
MOL File: 16836-31-0.mol

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kauran-16,17-diol Property

Melting point:: 193-194 °C
Boiling point:: 422.3±18.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 14.48±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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kauran-16,17-diol Chemical Properties,Usage,Production

Uses

Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].

References

[1] Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. DOI:10.1007/s10495-011-0638-5
[2] Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8. DOI:10.1016/j.bmcl.2014.11.059

kauran-16,17-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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kauran-16,17-diol

ent-kauran-16β,17-diol

ent-kauran

ent-Kaurane-16β,17-diol

(4aR,6aS,8R,9S,11aR,11bR)-8-(Hydroxymethyl)-4,4,11b-trimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalen-8-ol

Kauran-16,17-diol (ent-Kauran-16beta,17-diol)

inhibit,Inhibitor,Apoptosis,kauran16,17diol,kauran 16,17 diol

kauran-16,17-diol, 10 mM in DMSO

Kauran-16,17-diol/16836-31-0

16836-31-0